5652-11-9

Upstream product

• 703-61-7 2,4-dichloroquinoline 

Downstream Products

• 1257245-14-9 2,4-bis(4-phenylbut-1-ynyl)quinoline 
• 1257245-16-1 1,1'-((quinoline-2,4-diyl)bis(ethynyl))di(cyclohexanol) 
• 1257245-12-7 2,4-di(phenylethynyl)quinoline 
• 1257245-13-8 2,4-bis(p-tolylethynyl)quinoline 
• 1375478-49-1 5-(4-phenyl-1H-1,2,3-triazol-1-yl)tetrazolo[1,5-a]quinoline 
• 1375478-50-4 5-(4-(p-tolyl)-1H-1,2,3-triazol-1-yl)tetrazolo[1,5-a]quinoline 
• 1375478-51-5 5-(4-phenethyl-1H-1,2,3-triazol-1-yl)tetrazolo[1,5-a]quinoline 

Relevant academic research and scientific papers

Rewiring chemistry: Algorithmic discovery and experimental validation of one-pot reactions in the network of organic chemistry

Computational algorithms are used to identify sequences of reactions that can be performed in one pot. These predictions are based on over 86 000 chemical criteria by which the putative sequences are evaluated. The "raw" algorithmic output is then validated experimentally by performing multiple two-, three-, and even four-step sequences. These sequences "rewire" synthetic pathways around popular and/or important small molecules. Copyright

Pd/C-mediated dual C-C bond forming reaction in water: Synthesis of 2,4-dialkynylquinoline

Pd/C facilitated dual C-C bond forming reaction between 2,4-diiodoquinoline and terminal alkynes in water providing a practical and one-step synthesis of 2,4-dialkynylquinolines. A number of related quinoline derivatives were prepared in good to excellent yields using this water-based methodology. The use of other palladium catalysts and solvents was examined and the mechanism of the reaction has been discussed.