565203-62-5Relevant academic research and scientific papers
Enantioselective synthesis of the farnesyltransferase inhibitor, A-345665.0
Rozema, Michael J.,Fickes, Michael,McLaughlin, Maureen,Rohde, Bridget,McDermott, Todd
, p. 8765 - 8768 (2007/10/03)
The stereoselective synthesis of A-345665.0 1, a novel farnesyl transferase inhibitor, is described. The key step involves a stereoselective addition of an imidazolyl Grignard reagent to aldehyde 8 in the presence of an external chiral auxiliary. Crystall
Substituted phenyl farnesyltransferase inhibitors
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, (2012/09/25)
Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhibit farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
