56521-72-3

Basic information

• Product Name: 2-methoxyethyl bromoacetate
• CAS NO: 56521-72-3
• Molecular Formula: C₅H₉BrO₃
• Molecular Weight: 197.0272
• Mol File: 56521-72-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 214.1°C at 760 mmHg
• Flash Point: 83.3°C
• Density: 1.469g/cm³
• Vapor Pressure: 0.159mmHg at 25°C
• Refractive Index: 1.456
• CAS DataBase Reference: 2-methoxyethyl bromoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxyethyl bromoacetate(56521-72-3)
• EPA Substance Registry System: 2-methoxyethyl bromoacetate(56521-72-3)

Safety Data

• Hazardous Substances Data: 56521-72-3(Hazardous Substances Data)

Upstream product

• 22118-09-8 2-bromoacetyl chloride 
• 109-86-4 2-methoxy-ethanol 
• 598-21-0 2-Bromoacetyl bromide 
• 79-08-3 bromoacetic acid 
• 110-71-4 1,2-dimethoxyethane 

Downstream Products

• 42064-17-5 dioxa-3,6 heptanoate methoxy-2 ethyle 
• 3785-34-0 ethane-1,2-diyl bis(2-bromoacetate) 

Relevant articles and documents

Novel ibuprofen prodrugs with improved pharmacokinetics and non-ulcerogenic potential

In the present study, we evaluated the anti-inflammatory activity with pharmacokinetic, ulcerogenic properties of various synthesized prodrugs of ibuprofen in experimental animals. Prodrugs 2, 6, 9, 10, 12, and 14 were found to possess significant anti-inflammatory activity with almost non-ulcerogenic potential than standard drug ibuprofen 1a in both normal and inflammation-induced rats. Metabolic stability of prodrugs 2, 6, 9, 10, 12, and 14 were also studied in rat liver microsomes and oral bioavailability was determined by estimating area under curve (AUC) and plasma concentration of these prodrugs at various time intervals. The experimental findings elicited higher AUC and plasma concentration at 1 and 2 h indicating improved oral bioavailability as compared to parent ibuprofen. These prodrugs are found to have least gastric ulceration with retain anti-inflammatory activity observed in experimental animals. Therefore, present experimental findings demonstrated significant improvement of various pharmacokinetic properties with least ulcerogenic potential of ester prodrugs of ibuprofen an anti-inflammatory agent

Selective hydrogenation of trans-cinnamaldehyde and hydrogenolysis-free hydrogenation of benzyl cinnamate in imidazolium ILs

trans-Cinnamaldehyde is selectively hydrogenated to hydrocinnamaldehyde using a commercially available palladium catalyst in novel imidazolium ILs. The selective hydrogenation extends to benzyl cinnamate, in which the ester is protected from hydrogenolysis under similar conditions.

Bromoacetyl bromide: A versatile and selective cleaving agent for ethers and acetals

It is shown that bromoacetyl bromide can be utilized for the selective cleavage of ethers and acetals in high yields. With cyclic ethers and acetals as starting materials, cleavage products are produced with two strategically positioned bromo substituents which may be exploited for selective extention of the carbon chain.