565226-18-8

Upstream product

• 10212-13-2 3’,5’-O-acetyl-2’-deoxy-2’-fluorouridine 
• 56287-17-3 2'-deoxy-2'-fluorouridine 

Downstream Products

• 809232-63-1 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-[(E)-5-([2-(4-methoxy-benzylsulfanyl)-ethyl]-{2-[2-(4-methoxy-benzylsulfanyl)-ethylamino]-ethyl}-amino)-pent-1-enyl]-1H-pyrimidine-2,4-dione 
• 809232-62-0 5-{[2-(4-methoxybenzylsulfanyl)ethyl]{2-[2-(4-methoxybenzylsulfanyl)ethylamino]ethyl}amino}pent-4(E)-enyl-1-(3,5-diacetyl-2-fluoro-2-deoxy-1-β-D-ribofuranosyl)uracil 
• 55612-21-0 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione 

Relevant academic research and scientific papers

Cell-penetrating and neurotargeting dendritic siRNA nanostructures

We report the development of dendritic siRNA nanostructures that are able to penetrate even difficult to transfect cells such as neurons with the help of a special receptor ligand. The nanoparticles elicit strong siRNA responses, despite the dendritic str

NUCLEIC ACID CHEMICAL MODIFICATIONS

he present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) c

NON-NATURAL RIBONUCLEOTIDES, AND METHODS OF USE THEREOF

One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such modified nucleosides. Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) co

Synthesis of a technetium-99m-labeled thymidine analog: A potential HSV1-TK substrate for non-invasive reporter gene expression imaging

{2-[5-(2′-Fluoro-2′-deoxyuridin-5-yl)pent-4(E)-enyl] [2-(2-mercaptoethyl)aminoethyl]aminoethanethiolato(3)-N,N′,S,S′} oxo-[99mTc]technetium(V), a potential viral thymidine kinase substrate, was synthesized by coupling 2′-fluoro-2′-deoxyuridine

Functionalized nucleoside 5'-triphosphates for in vitro selection of new catalytic ribonucleic acids

A series of novel 2'-modified nucleoside 5'-triphosphates was synthesized. The amino, imidazole, and carboxylate functionalities were attached to the 5-position of pyrimidine base of these molecules through alkynyl and alkyl spacers, respectively. Two different phosphorylation methods were used to optimize the yields of these highly modified triphosphates. (C) 2000 Elsevier Science Ltd. All rights reserved.