10212-13-2 Usage
Description
3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE is a synthetic nucleoside analogue that demonstrates potential in the treatment of various cancers. It functions as an orally active prodrug of 2'-deoxy-2'-fluorouridine, a potent inhibitor of RNA synthesis and DNA replication in cancer cells. 3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE is engineered for selective activation within cancer cells, facilitating targeted destruction of malignant tissues. Its favorable pharmacokinetic properties enhance its distribution and accumulation in tumor tissues, making it a promising candidate for cancer therapy.
Uses
Used in Oncology:
3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE is used as an anticancer agent for its ability to inhibit RNA synthesis and DNA replication in cancer cells. It is particularly effective due to its selective activation in cancer cells, which allows for targeted therapy with minimal impact on healthy cells.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE is used as a prodrug, indicating its potential for development into a novel cancer treatment. Its favorable pharmacokinetics make it a candidate for further research and clinical trials to assess its safety, efficacy, and optimal dosing regimens in cancer therapy.
Used in Drug Delivery Research:
3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE is utilized in research aimed at improving drug delivery systems for cancer treatment. Its properties are being studied to enhance the compound's bioavailability, distribution, and accumulation in tumor tissues, potentially leading to more effective cancer therapies with fewer side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 10212-13-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,2,1 and 2 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 10212-13:
(7*1)+(6*0)+(5*2)+(4*1)+(3*2)+(2*1)+(1*3)=32
32 % 10 = 2
So 10212-13-2 is a valid CAS Registry Number.
10212-13-2Relevant articles and documents
Cell-penetrating and neurotargeting dendritic siRNA nanostructures
Brunner, Korbinian,Harder, Johannes,Halbach, Tobias,Willibald, Julian,Spada, Fabio,Gnerlich, Felix,Sparrer, Konstantin,Beil, Andreas,M?ckl, Leonhard,Br?uchle, Christoph,Conzelmann, Karl-Klaus,Carell, Thomas
, p. 1946 - 1949 (2015)
We report the development of dendritic siRNA nanostructures that are able to penetrate even difficult to transfect cells such as neurons with the help of a special receptor ligand. The nanoparticles elicit strong siRNA responses, despite the dendritic str
Synthesis method of 2 ’ -fluoro -2 ’ - deoxyuridine and intermediate thereof
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Paragraph 0090-0092, (2021/11/26)
The synthesis method of 2 ’ -fluoro -2 ’ - deoxyuridine is novel in synthetic route, simple and convenient to operate, high in yield, good in safety, free of column chromatography and suitable for industrial production. Among them R is a hydroxyl protecting group, most preferably a tetrahydropyranyl group (THP group) as a hydroxyl protecting group. R is a conventional protecting group for the hydroxyl group in the art, and R THP
NON-NATURAL RIBONUCLEOTIDES, AND METHODS OF USE THEREOF
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Page/Page column 151-152, (2009/10/22)
One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such modified nucleosides. Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) co
