565229-53-0

Upstream product

• 565229-91-6 (6Z,11Z)-(2R,3R,8S,9R,10S)-3,9-Bis-(4-methoxy-benzyloxy)-14-((2S,3S,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyl-tetrahydro-pyran-2-yl)-2,8,10-trimethyl-tetradeca-6,11-dien-1-ol 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 154919-93-4 (S)-4-Benzyl-3-[(2S,3R)-6-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-hexanoyl]-oxazolidin-2-one 
• 479673-37-5 (2S)-2-[(4R,5S)-2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propan-1-ol 
• 183565-25-5 (R)-4-Benzyl-3-[(2R,3S,4S)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-pentanoyl]-oxazolidin-2-one 
• 444105-66-2 (3R,4S,5S)-4-[(tert-butyldimethylsilanyl)oxy]-3,5-dimethyltetrahydropyran-2-one 
• 470467-70-0 (3R,4S,5S,6S)-6-allyl-4-tert-butyldimethylsilyloxy-3,5-dimethyltetrahydropyran-2-one 
• 479673-49-9 (4R,5R)-tert-butyl-{3-[2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane 
• 479673-36-4 (2S)-tert-butyl-{(4R,5S)-2-[2-(4-methoxyphenyl)-5-methyl[1,3]dioxan-4-yl]propoxy}dimethylsilane 
• 565228-95-7 (2S,3R,4S,5R,6R)-2-allyl-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran 
• 565229-49-4 (4S,5R)-4-{(3Z,5S,6S,7S,8Z)-6-(4-methoxybenzyloxy)-11-[(2S,3R,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-5,7-dimethylundeca-3,8-dienyl}-2-(4-methoxyphenyl)-5-methyl[1,3]dioxane 
• 565229-28-9 (4R,5S)-4-{(1S,2Z)-5-[(2S,3R,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-1-methylpent-2-enyl}-2-(4-methoxyphenyl)-5-methyl[1,3]dioxane 
• 565229-36-9 (2R,3S,4S,5Z)-3-(4-methoxybenzyloxy)-8-[(2S,3R,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-2,4-dimethyloct-5-enal 
• 565229-81-4 3-((2S,3S,4S,5R,6R)-6-Methoxy-4-methoxymethoxy-3,5-dimethyl-tetrahydro-pyran-2-yl)-propan-1-ol 

Downstream Products

• 565229-57-4 carbamic acid, (1S,2S,3R,6Z,8S,9S,10S,11Z)-1-isopropyl-3,9-bis(4-methoxybenzyloxy)-14-[(2R,3R,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyltetrahydropyran-2-yl]-2,8,10-trimethyltetradeca-6,11-dienyl ester 
• 565229-93-8 (8Z,13Z)-(3S,4R,5R,10S,11R,12S)-5,11-Bis-(4-methoxy-benzyloxy)-16-((2S,3S,4S,5R,6R)-6-methoxy-4-methoxymethoxy-3,5-dimethyl-tetrahydro-pyran-2-yl)-2,4,10,12-tetramethyl-hexadeca-8,13-dien-3-ol 

Relevant academic research and scientific papers

Simplified discodermolide analogues: Synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents

Several novel analogues of (+)-discodermolide were synthesized via a convergent strategy that used Wittig reactions to append left and right side chains to a central scaffold and then tested for biological activity. Three of the analogues in the 4-epi-7-d