56527-35-6Relevant academic research and scientific papers
A novel and facile reaction to N6-alkylated adenosine via benzotriazole as a synthetic auxiliary
Afify, Hanan M. N. M.,Pedersen, Erik B.,Zahran, Magdy A.
, p. 339 - 341 (2007/10/03)
The reaction of benzotriazole with aliphatic, aromatic or heteroaromatic aldehyde and adenosine leads to a benzotriazole adduct which is reduced with sodium borohydride to the corresponding N6-alkylated adenosine derivatives. This procedure is also utilized in a new route to N6-(3- iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) which is considered an important adenosine agonist at A3 adenosine receptors.
Synthesis of substituted-benzyl and sugar-modified analogues of 6-N-(4- nitrobenzyl)adenosine and their interactions with 'ES' nucleoside transport systems
Robins,Asakura,Kaneko,Shibuya,Jakobs,Agbanyo,Cass,Paterson
, p. 1627 - 1646 (2007/10/02)
Four classes of 6-X-benzylated purine nucleosides, (i) 6-N-(substituted- benzyl)adenosines, (ii) 6-N-(4-nitrobenzyl)adenine nucleosides with modified sugars, (iii) 6-N(S)-(4-azidobenzyl) derivatives of adenosine, 6-thioinosine, and 6-thioguanosine, and (iv) 6-N-{4-N-[acyl(sulfonyl)amino]benzyl} adenosines, were synthesized and their binding interactions with 'es-NT' (equilibrative, inhibitor-sensitive nucleoside transport) systems were studied. Several tight-binding analogues were found.
