5653-07-6

Upstream product

• 4927-55-3 1,2-bis(3,4-dimethoxyphenyl)ethanone 
• 5653-60-1 3,3',4,4'-tetramethoxybenzoin 

Downstream Products

• 239448-46-5 4,5-bis(3,4-dimethoxyphenyl)-2-methylthiazole 
• 239448-47-6 2-amino-4,5-bis(3,4-dimethoxyphenyl)thiazole 
• 97059-65-9 5,6-bis-(3,4-dimethoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 

Relevant academic research and scientific papers

A simple route to new phenanthro- and phenanthroid-fused thiazoles by a PIFA-mediated (hetero)biaryl coupling reaction

An application of the PIFA-mediated [PIFA: phenyliodine(III) bis(trifluoroacetate) biaryl coupling reaction is presented and extended to the formation of heterobiaryl connections. A preliminary study of the scope and limitations of this procedure was carried out in the synthesis of phenanthroids 11 from a series of phenethyl-substituted heterocycles 10, It was observed that in some cases a competitive dimerization process took place. It was also found that the coupling step could be efficiently extended to a larger number of examples if an aromatic ring were situated fused to the 1,2-diarylethane skeleton, as in 23 and 30. The synthesis of a series of 4,5-diarylthiazoles 23a-g was therefore carried out to explore the electronic requirements and the regioselectivity of the PIFA-mediated non-phenolic coupling reaction. When the same procedure was applied to aryl-heteroarylthiazoles 30, a series of phenanthroid-fused thiazoles 31 was obtained in good overall yields. To the best of our knowledge, no oxidative aryl-heteroaryl coupling reaction of this type had previously been reported. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.