5653-12-3

Usage

Type of compound

ketone

Structure

A derivative of quinoline with a phenyl group attached to the carbonyl carbon

Biological activity

Potential inhibitor of the enzyme cholinesterase

Function

Involved in the breakdown of the neurotransmitter acetylcholine

Potential use

Treatment of neurodegenerative diseases such as Alzheimer's

Note

Further research is needed to fully understand its biological effects and potential applications.

Upstream product

• 70-11-1 α-bromoacetophenone 
• 767-92-0 decahydroquinoline 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 88920-05-2 2,2a,3,4-tetrahydro-2-phenyl-1H-azeto<1,2-a>quinolin-2-ol 
• 98-86-2 acetophenone 

Relevant academic research and scientific papers

Synthesis of chiral alcohols by asymmetric reductions of various ketones including α-aminophenones

LiAlH4 previously treated with 2.5 equiv. of (S)-(+) or (R)-(-)-2-(2-isoindolinyl)butan-1-ol 1 reduced the six α-aminophenones 4-9 into the corresponding optically active β-aminoalcohols 10-15 whose ee's were in the range of 40-97% after chroma

Photoreactions of α-Amino Ketones Derived from Heterocyclic Secondary Amines

The photochemical behaviour of N-phenacyl nitrogen heterocycles varies with the size of the heterocyclic ring.U.v. irradiation of 1-phenacylindoline and 2,3,3-trimethyl-1-phenacylindoline resulted in type-II fission to give acetophenone and indole or 2,3,3-trimethyl-3H-indole, respectively.Indole was also produced, along with 2,3-diphenylbutane-2,3-diol, when indoline was irradiated with acetophenone.Both 1-phenacyl- and 1-(2-oxocyclohexyl)-1,2,3,4-tetrahydroquinoline underwent type-II cyclisation to azetidinol derivatives; fission was a minor process.In contrast, on irradiation of 5,6-dihydro-5- phenacylphenanthridine, type-II fission occurred to give acetophenone and phenanthridine.Irradiation of 2,3,4,5-tetrahydro-1-phenacyl-1H-benzazepine resulted in direct homolysis of the N-CH2CO bond to yield 2,3,4,5-tetrahydro-1H-benzazepine as the major product.