5653-46-3

Basic information

• Product Name: 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID
• Synonyms: 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID;3,4-DIMETHOXYSALICYLIC ACID;3,4-DIMETHOXY-2-HYDROXYBENZOIC ACID;AKOS 244-33;HYDROXY-3,4-DIMETHOXYBENZOIC ACID, 2-;2-Hydroxy-3,4-dimethoxybenzoic;2-HYDROXY-3,4-DIMETHOXYBENZOICCID 97%;3,4-DIMETHOXYSALICYLIC ACID 97%
• CAS NO: 5653-46-3
• Molecular Formula: C₉H₁₀O₅
• Molecular Weight: 198.17
• EINECS: 227-096-9
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 5653-46-3.mol

Chemical Properties

• Melting Point: 170-172℃
• Boiling Point: 334℃
• Flash Point: 134℃
• Appearance: /
• Density: 1.335
• Vapor Pressure: 5.13E-05mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID(5653-46-3)
• EPA Substance Registry System: 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID(5653-46-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 5653-46-3(Hazardous Substances Data)

Usage

Uses

Since the provided materials do not specify the uses of 2-Hydroxy-3,4-dimethoxybenzoic acid, it is not possible to list its applications as done for Gallotannin. However, given its chemical structure, it can be hypothesized that it may have potential uses in the following areas:
Used in Pharmaceutical Industry:
2-Hydroxy-3,4-dimethoxybenzoic acid could be used as a starting material or intermediate in the synthesis of pharmaceutical compounds, given its phenolic and carboxylic acid groups, which are common in drug molecules.
Used in Chemical Synthesis:
It may serve as a building block in the synthesis of more complex organic molecules, such as natural products, agrochemicals, or other specialty chemicals, due to its unique functional groups.
Used in Material Science:
2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID could potentially be incorporated into the development of new materials, such as polymers or coatings, where its phenolic and carboxylic acid groups could contribute to desired properties like adhesion, stability, or reactivity.

InChI:InChI=1/C9H10O5/c1-13-6-4-3-5(9(11)12)7(10)8(6)14-2/h3-4,10H,1-2H3,(H,11,12)

Upstream product

• 186581-53-3 diazomethane 
• 60-29-7 diethyl ether 
• 56128-66-6 2,3,4-trihydroxybenzoic acid methyl ester 
• 610-02-6 2,3,4-trihydroxybenzoic acid 
• 77-78-1 dimethyl sulfate 
• 1178885-42-1 5,2'-dihydroxy-8,3',4'-trimethoxyflavone 
• 573-11-5 2,3,4-Trimethoxy-benzoic acid 
• 93-07-2 Veratric acid 
• 5150-42-5 2,3-dimethoxyphenol 
• 67-64-1 acetone 
• 22425-59-8 (2R)-2r-(3,4-Dimethoxy-phenyl)-7,8-dimethoxy-chroman-3c,4c-diol 
• 90844-23-8 (2-hydroxy-3,4-dimethoxy-phenyl)-glyoxylic acid 
• 6395-23-9 methyl 2-hydroxy-3,4-dimethoxy-benzoate 
• 91498-01-0 (2-hydroxy-3,4-dimethoxy-phenyl)-glyoxylic acid ethyl ester 

Downstream Products

• 6395-23-9 methyl 2-hydroxy-3,4-dimethoxy-benzoate 
• 104398-04-1 2-ethoxy-3,4-dimethoxy-benzoic acid 
• 5150-42-5 2,3-dimethoxyphenol 
• 3934-81-4 2,3-dihydroxy-4-methoxybenzoic acid 
• 5653-45-2 2,5-dihydroxy-3,4-dimethoxy-benzoic acid 
• 100619-79-2 2-ethoxy-3,4-dimethoxy-benzoic acid ethyl ester 
• 960063-82-5 ethyl 2-hydroxy-3,4-dimethoxybenzoate 
• 1569083-95-9 C₁₁H₁₅N₃O₅ 
• 1569083-94-8 C₁₃H₁₇NO₆ 
• 1035572-38-3 2-{6-[2-(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide 
• 1035573-64-8 methyl 3,4-dimethoxy-2-[2-oxo-2-(propylamino)ethoxy]benzoate 
• 52643-52-4 2,3-dimethoxybenzene-1,4-diol 
• 72023-44-0 2,3,4,5-tetramethoxybenzoic acid 
• 50625-48-4 2,3,4-trimethoxyaniline 

Relevant articles and documents

TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF

The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS

Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

Chemical constituents of Limnophila indica

Two flavonoids, 5,6-dihydroxy-7,8,4′-trimethoxy flavone 1 and 5,2′-dihydroxy-8,3prime;,4′-trimethoxyflavone 2 together with three known compounds, 5-hydroxy-7,2′-dimethoxyflavone 3, 5,2′-dihydroxy- 7,8-dimethoxyflavone 4 and β-sitosterol 5, have been isolated from the aerial parts and roots of Limnophila indica (Scrophulariaceae). The structures of compounds 1-5 have been elucidated on the basis of spectral and chemical studies.

Competition of substituents for ortho direction of metalation of veratric acid

LTMP (5 equiv) metalates randomly veratric acid (1). Under external quench conditions, the thermodynamically more stable lithium 2-lithio-3,4-dimethoxybenzoate (2) reacts with a variety of electrophiles to give versatile building units that are not easily accessible by conventional means. Under in situ quench conditions (LTMP/TMSCl), a reversal of regioselectivity is observed and 6-trimethylsilyl-3,4-dimethoxybenzoic acid (10) is formed predominantly.

Structure-activity relationship studies on UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Part 5: Roles of the 9-membered dilactone-ring moiety in respiratory inhibition

Several open-chained analogues of UK-2A, a novel antifungal antibiotic isolated from Streptomyces sp. 517-02, were prepared for structure-activity studies. The in vitro antifungal activities of these compounds against Rhodotorula mucilaginosa IFO 0001 and the inhibition of uncoupler-stimulated respiration in bovine heart submitochondrial particles (SMP) were evaluated. Oxidative potentials were measured by cyclic voltammetry. An analogue prepared from dihexyl l-glutamate showed comparable inhibitory activity as UK-2A.