5653-51-0Relevant articles and documents
ANTIBACTERIAL COMPOUNDS
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Page/Page column 192; 193, (2013/04/24)
The present Invention relates to cephalosporin antibacterial compounds of Formula (!): corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods for bacterial infections, especially those caused by gram-negative bacteria.
NEW DS DNA BINDING FLUORESCENT DYES
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Page/Page column 29; Sheet 8, (2008/12/05)
The present invention is directed to a fluorescent dye comprising a benzothiazolium moiety and a pyrimidinium moiety connected by a mono-methine bridge, characterized in that (i) the 2-position of the pyrimidine carries a substituent which starts with a C
FUSED-RING PYRIMIDIN-4(3H)-ONE DERIVATIVES, PROCESSES FOR THE PREPARATION AND USES THEREOF
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Page 298, (2010/02/06)
AbstractNovel compounds of the following formula (I) and pharmacologically acceptable salt and esters thereof can modulate LXR function and as a result show excellent anti-arteriosclerotic and anti-inflammatory activity:wherein:A represents aryl or heteroaryl;R1, R2 and R3 are the same or different and each represents hydrogen, hydroxyl, nitro, cyano, amino, halogen, carboxy, carbamoyl, mercapto, alkyl, haloalkyl, alkylcarbonyloxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino, alkylcarbonylamino, N-(alkylcarbonyl)-N-(alkyl)amino, alkoxycarbonylamino, N-(alkoxycarbonyl)-N-(alkyl)amino, alkylsulfonylamino, N-(alkylsulfonyl)-N-(alkyl)amino, haloalkylsulfonylamino, N-(haloalkylsulfonyl)-N-(alkyl)amino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group, or R1 and R2 together are alkylenedioxy;R4 and R5 are the same or different and each represents hydrogen, hydroxyl, amino, halogen, mercapto, alkyl, haloalkyl, alkoxy, alkoxycarbonyl or alkylthio;X represents hydrogen, hydroxyl, halogen, alkoxy or haloalkoxy; andY represents an optionally substituted alkyl, cycloalkyl, heterocyclyl, aryl, cycloalkylalkyl, heterocyclylalkyl or aralkyl group.
Substituted quinazolinediones
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, (2008/06/13)
The synthesis of 5,6-dioxy substituted quinazolinediones is described. The novel quinazolinediones are useful as cardiotonic agents.
Substituted 5,6-dialkoxyquinazoline derivatives
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, (2008/06/13)
Quinazoline derivatives having an oxy substituent in 5 and 6 positions are described. The novel quinazoline derivatives are useful as cardiotonic agents.
Process for the preparation of 5,6-dialkoxyanthranilic acids
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, (2008/06/13)
A process for the preparation of 5,6-dialkoxyanthranilic acids is described. The 5,6-dialkoxyanthranilic acids are useful in the preparation of substituted quinazolinediones which are active cardiotonic agents.
A Regioselective Entry to 13-Substituted 8-Oxoprotoberberines. Total Synthesis of (+/-)-Corydaline
Saa, Carlos,Guitian, Enrique,Castedo, Luis,Suau, Rafael,Saa, Jose Manuel
, p. 2781 - 2784 (2007/10/02)
13-Alkyl and 13-aryl substituted 8-oxoprotoberberines were obtained by interamolecular benzyne cycloaddition of isoquinolinopyrrolinediones with arynes.This convergent and highly regioselective reaction has been applied to the synthesis of (+/-)-corydalin
Synthesis of 2-(Alkylamino)-5,6- and -6,7-dihydroxy-3,4-dihydroquinazolines and Evaluation as Potential Dopamine Agonists
Grosso, John A.,Nichols, David E.,Kohli, Jai D.,Glock, Dana
, p. 703 - 708 (2007/10/02)
Based upon the known dopaminergic properties of 2-aminodihydroxy-1,2,3,4-tetrahydronaphthalenes (ADTN's), heterocyclic congengers were prepared.Several 2-(alkylamino)-5,6- and -6,7-dihydroxy-3,4-dihydroquinazolines were synthesized and tested for a dopami