56535-85-4

Usage

Uses

Used in Pharmaceutical Industry:
1-PHENYL-TETRAHYDRO-2(1H)-PYRIMIDINONE is used as a building block for the synthesis of various drugs and organic compounds. Its potential biological activities make it a promising candidate for the development of new pharmaceuticals with therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 1-PHENYL-TETRAHYDRO-2(1H)-PYRIMIDINONE is utilized as a precursor for the synthesis of molecules with pharmacological properties, contributing to the development of new agrochemicals for crop protection and other agricultural applications.

InChI:InChI=1/C10H12N2O/c13-10-11-7-4-8-12(10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)

Upstream product

• 5259-97-2 [1,3]oxazinan-2-one 
• 62-53-3 aniline 
• 117784-31-3 (3-Phenylamino-propyl)-carbamic acid ethyl ester 
• 17758-13-3 1-phenyl-2(1H)-pyrimidinone 
• 3420-63-1 N-(3-Chloropropyl)-N'-phenylurea 
• 4742-01-2 N-(3-aminopropyl)aniline 

Downstream Products

• 91180-81-3 1-Phenyl-3-methyl-3,4,5,6-tetrahydropyrimidin-2(1H)-one 
• 1350900-47-8 1-(5-([1,4'-bipiperidin]-1'-yl)-1,3,4-thiadiazol-2-yl)-3-phenyltetrahydropyrimidin-2(1H)-one 
• 1311946-41-4 4-(tetrahydro-2-oxopyrimidin-1(2H)-yl)benzene-1-sulfonyl chloride 
• 1311946-34-5 4-fluorophenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-32-3 4-chlorophenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-30-1 4-tolyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-29-8 3,4,5-trimethoxyphenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-28-7 3-fluorophenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-27-6 3-methoxyphenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-26-5 3-tolyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-24-3 2,4,6-trichlorophenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-22-1 2,4,5-trichlorophenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-20-9 2,4-dimethylphenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-19-6 2-propylphenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 

Relevant academic research and scientific papers

Design, synthesis, biological evaluation, and Structure - Activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4

Sixty-one phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates (PIB-SOs) and 13 of their tetrahydro-2-oxopyrimidin-1(2H)-yl analogues (PPB-SOs) were prepared and biologically evaluated. The antiproliferative activities of PIB-SOs on 16 cancer cell lines are

SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS

Compounds of formula (I): wherein R1, R2, R3, R4, R7, R6, R7, R8, R9, A, X and Y as defined herein are provided as useful for the treatment of cancer or for

COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS

Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.

Cyclic ureas as ortho directing substituents

Six-membered cyclic ureas are shown to have a weak ortho directing ability when linked through nitrogen to benzene and pyridine rings.

New substituted 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl derivatives with α2-adrenoceptor antagonist activity

The emergence of a novel theory concerning the role of noradrenaline in the progression and the treatment of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases has provided a new impetus toward the discovery of novel compounds acting at α2-adrenoceptors. A series of substituted 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl derivatives bearing an amide, urea, or imidazolidinone moiety was studied. Some members of this series of compounds proved to be potent α2-adrenoceptor antagonists with good selectivity versus α1-adrenergic and D2-dopamine receptors. Particular emphasis is given to compound 33g which displays potent α2-adrenoceptor binding affinity in vitro and central effects in vivo following oral administration.

3-(piperid-4-yl)-1,2-benzisoxazole and 3-(piperazin-4-yl)-1,2-benzisoxazole compounds

Compounds of formula: STR1 wherein: A, m, n, E and Y are as defined in the description, the optical isomers thereof and the physiologically-tolerable salts thereof. These compounds, their optical isomers and their physiologically-tolerable salts, can be u

sYNTHESIS OF N,N'-DISUBSTITUTED UREAS FROM CARBAMATES

A simple synthesis of N,N'-disubstituted ureas from carbamates is described involving displacement of an alkoxy group by the magnesium salt of an amine generated in situ by treatment with ethylmagnesium bromide.

Controlled Reduction of Pyrimidin(e)-2(1H)-ones and -thiones with Metal Hydride Complexes. Regioselective Preparation of Dihydro- and Tetrahydro-pyrimidin-2(1H)-ones and the Corresponding Thiones

1,4,6-Trisubstituted pyrimidin-2(1H)-ones were easily reduced with sodium borohydride to give mixtures of 3-aryl-3,4-dihydro-, 1-aryl-3,4-dihydro-, and 3,4,5,6-tetrahydro-pyrimidin-2(1H)-ones.The ratio of the three products was dramatically dependent on t