56536-44-8Relevant academic research and scientific papers
BIS HETEROARYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION
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Page/Page column 18, (2012/06/01)
This invention relates to thiazole I and its therapeutic and prophylactic uses, wherein the variables A, Q, J, R1, R3, and R5 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.
METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION
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, (2012/12/13)
This invention relates to methods for preventing, treating or ameliorating an MMP9 and/or MMP13 mediated syndrome, disorder or disease comprising administering to a subject in need thereof an effective amount of a compound listed in the examples section of this specification, or a form, composition or medicament thereof. Disorders treated and/or prevented include rheumatoid arthritis.
Imidazotriazines as Potential Antiasthma Agents
Paul, Rolf,Brockman, John A.,Hallett, W. A.,Hanifin, John W.,Tarrant, M. Ernestine,et al.
, p. 1704 - 1716 (2007/10/02)
By using inhibition of histamine release from antigen-challenged, sensitized human basophils as a means of identifying a potentialy prophylactic drug for the treatment of asthma, a series of substituted imidazotriazines were found, which wer
Process for preparing 1-substituted-6-n-propyl-8-methylimidazo[1,5-d]-as-triazin-4(3H)-ones
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, (2008/06/13)
This disclosure describes a novel process for the preparation of 1-(lower alkyl)substituted derivatives of 6-n-propyl-8-alkylimidazo[1,5-d]-as-triazin-4(3H)-ones which are useful as anti-asthmatic agents.
2-GUANIDINO-4-HETEROARYL-THIAZOLES
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, (2008/06/13)
A series of 2-guanidino-4-heteroarylthiazoles, wherein the heteroaryl substituent is selected from thiazolyl, triazolyl, imidazolyl, and 2-alkyl, 2-amino and 2-carboxamido derivatives thereof, are disclosed. The novel compounds have activity as antisecretory agents and histamine H 2 antagonists and are useful for the treatment of gastric hyperacidity and peptic ulcers. Also disclosed are pharmaceutical compositions containing the novel compounds of this invention and a method of using the compounds in the treatment of gastric hyperacidity and peptic ulcers. Novel intermediates useful in the preparation of the novel antisecretory compounds are also described.
