5654-83-1

Usage

Uses

Used in Organic Synthesis:
DBU is used as a strong, non-nucleophilic base in various organic reactions, such as deprotonation, alkylation, and rearrangements. Its ability to act as a base without being nucleophilic makes it a versatile reagent in organic synthesis.
Used in Catalysts for Polymer, Pharmaceutical, and Fine Chemical Synthesis:
DBU serves as an effective catalyst in the synthesis of polymers, pharmaceuticals, and fine chemicals. Its strong basic properties facilitate various chemical transformations, enhancing the efficiency and selectivity of these syntheses.
Used in Medicinal Chemistry and Drug Discovery:
DBU has been studied for its potential applications in the field of medicinal chemistry and drug discovery. Its unique molecular structure and strong basic properties make it a promising candidate for the development of new drugs and therapeutic agents.

InChI:InChI=1/C7H14N2/c1-2-7-6-8-3-5-9(7)4-1/h7-8H,1-6H2

Upstream product

• 88327-63-3 2,3-dioxo-1,4-diazabicyclo<4.3.0>nonane 
• 19179-12-5 Hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione 
• 71257-37-9 3,4-dihydropyrrolo[1,2-a]-pyrazine 
• 16620-61-4 1,4-diazabicyclo<4.3.0>nonan-5-one 
• 96163-75-6 N-Chloroacetyl-DL-proline ethyl ester 
• 609-36-9 rac-Pro-OH 
• 60169-67-7 ethyl pyrrolidine-2-carboxylate 
• 57734-57-3 2-amino-methylpyrrolidine 

Downstream Products

• 49864-70-2 DL-10-<β-N-(1,4-Diazabicyclo<4.3.0>nonanyl)propionyl>-2-chlorophenothiazine 
• 54063-26-2 Nonaphthazin 
• 88327-68-8 4-(β-phen yl-β-hydroxyethyl)-1,4-diazabicyclo<4.3.0>nonane 
• 88327-69-9 1-(Hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-3-phenoxy-propan-2-ol 
• 80276-11-5 (Hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-(4-nitro-phenyl)-methanone 
• 88327-70-2 4-(2-oxo-4-n-butyl)-1,4-diazabicyclo<4.3.0>nonane 
• 88327-67-7 4-(β-phenylethyl)-1,4-diazabicyclo<4.3.0>nonane 
• 88327-66-6 4-ethyl-1,4-diazabicyclo<4.3.0>nonane 
• 78816-43-0 3-Carbethoxyamino-5-β-(1,4-diazabicyclo<4.3.0>non-4-yl)propionyl-iminodibenzyl 
• 2856-81-7 1-(4-fluoro-phenyl)-4-(hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-butan-1-one 
• 80276-16-0 (4-Amino-phenyl)-(hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-methanone 
• 39186-48-6 4-(hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-2,2-diphenyl-butyronitrile 
• 1035271-13-6 methyl 4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c]pyrazin-2-yl)benzoate 
• 1035269-99-8 5-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c]pyrazin-2-yl)-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]pyrazine-2-carboxamide 

Relevant academic research and scientific papers

6' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1—R4 A, B, D, E, and G are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Unusual rearrangement of spiro β-lactams to 1,4-diazabicyclo[4,4,0] decanes and 1,4-diazabicyclo[4,3,0]nonanes. Synthesis of conformationally restricted σ-receptor ligands

Synthesis of 1,4-diazabicyclo[4,4,0]decanes and 1,4-diazabicyclo[4,3,0] nonanes was achieved by using 4-formyl spiro β-lactams as easily available starting materials. Furthermore, the application of this protocol to the preparation of conformationally res

Studies in Potential Filaricides: Part XIII - Synthesis of 1,4-Diazabicyclononanes, 1,4-Diazabicyclodecanes and 1,4-Diazabicycloundecanes as diethylcarbamazine Analogs

1,4-Diazabicyclononanes (13 - 20), 1,4-diazabicyclodecanes (21 - 28), 1,4-diazabicycloundecanes (29 - 34), 1,4-diazabicyclononan-5-ones (37 - 41) and 1,4-diazabicyclodecan-5-ones (42 - 44) having alkyl and acyl substituents at 4-position have been synthesized and evaluated for their filaricidal activity against Litomasoides carinii infection in cotton rats.Except 4-diethylcarbamoyl-1,4-diazabicyclononane (13), which exhibits significant activity, being about 3/5th as active as the standard diethylcarbamazine (DEC), none of the other compounds shows any activity against adult worms.The results have been rationalised in terms of critical bulk around the N-1 of the piperazine ring of DEC.From this work and earlier published results it appears that both axial and equatorial N-CH3 bonds in DEC are acceptable for activity.