60169-67-7

Basic information

• Product Name: Ethyl pyrrolidine-2-carboxylate
• Synonyms: Ethyl pyrrolidine-2-carboxylate;DL-Proline ethyl ester HCl
• CAS NO: 60169-67-7
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18362
• Mol File: 60169-67-7.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl pyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl pyrrolidine-2-carboxylate(60169-67-7)
• EPA Substance Registry System: Ethyl pyrrolidine-2-carboxylate(60169-67-7)

Safety Data

• Hazardous Substances Data: 60169-67-7(Hazardous Substances Data)

Usage

General Description

Ethyl pyrrolidine-2-carboxylate is a chemical compound with the molecular formula C7H12NO2. It is a derivative of the organic compound pyrrolidine, containing an ethyl ester group and a carboxylate group. Ethyl pyrrolidine-2-carboxylate has applications in pharmaceuticals, specifically in the synthesis of various pharmaceutical intermediates. It also has potential uses in the development of new drug molecules due to its structural characteristics. Ethyl pyrrolidine-2-carboxylate may also have uses in the field of organic chemistry and chemical research due to its unique structure and reactivity.

Upstream product

• 64-17-5 ethanol 
• 147-85-3 L-proline 
• 609-36-9 rac-Pro-OH 
• 26166-36-9 pyrrolidine-2-carboxylic acid hydrochloride 
• 634-97-9 pyrrole-2-carboxyl acid 
• 161362-39-6 ethyl cis-6-ethoxy-1,2-oxazinane-3-carboxylate 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 112135-47-4 ethyl 6-ethoxy-5,6-dihydro-4H-1,2-oxazine-3-carboxylate 
• 43041-12-9 methyl pyrrolidine-2-carboxylate 

Downstream Products

• 98430-75-2 DL-prolin-(2-amino-ethylamide) 
• 2812-47-7 pyrrolidine-2-carboxylic acid amide 
• 107672-34-4 1-[2-(3,4-Dimethoxy-phenyl)-acetyl]-pyrrolidine-2-carboxylic acid ethyl ester 
• 55661-98-8 ethyl 1-(o-aminobenzyl)pyrrolidine-2-carboxylate 
• 1159275-23-6 1-[(6-bromo-2-methoxy-quinolin-3-yl)-phenylmethyl]-pyrrolidine-2-carboxylic acid ethyl ester 
• 55661-97-7 ethyl 1-(o-nitrobenzyl)pyrrolidine-2-carboxylate 
• 105770-46-5 1-(1,3-dithiol-2-ylidene)-2-ethoxycarbonyl pyrrolidinium perchlorate 
• 107672-35-5 1-[2-(3,4-Dimethoxy-phenyl)-acetyl]-pyrrolidine-2-carboxylic acid 
• 19179-12-5 Hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione 
• 5654-83-1 octahydropyrrolo[1,2-a]pyrazine 
• 49864-70-2 DL-10-<β-N-(1,4-Diazabicyclo<4.3.0>nonanyl)propionyl>-2-chlorophenothiazine 
• 575452-35-6 1-(tert-butyl) 2-ethyl pyrrolidine-1,2-dicarboxylate 

Relevant articles and documents

TRICYCLIC FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF p97 COMPLEX

Tricyclic fused pyrimidine compounds having an arylalkyl amine substituent at the P4 position and a substituted 1H-indol-1-yl, 1H-indol-3-yl, indanyl, indazol-1-yl, indazol-3-yl, benzotriazol-1-yl or 1H-benz[d]imidazol-1-yl group at the P2 position well as optional aliphatic, functional and/or aromatic components substituted at other positions of the tricyclic compounds of the invention. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.

Pentacoordinated chlorosilanes with C,O-chelate ligands derived from N-methyl-N’-organosulfonyl-prolinamides

The reaction of amides RSO2-Pro-NHMe with ClCH2SiMe2Cl in the presence of (Me3Si)2NH gave pentacoordinatedchlorosilanes RSO2-Pro-N(Me)CH2SiMe2Cl with an organosulfonyl group (R = Me, Ph, 4-ClC6H4, 4-BrC6H4, 4-MeC6H4, and 4-O2NC6H4) attached to the proline nitrogen atom. An alternative method for the preparation of these compounds comprises the cyclosilylmethylation of proline methylamide by dimethylchloromethylchlorosilane to give the previously unreported heterocyclic 2-sila-5-piperazinone system in the first step. The bicyclic silacyclane synthesized is 2-sila-5-piperazinone condensed with a proline residue. The action of sulfonyl chlorides RSO2Cl leads to cleavage of the sila ring Si–N bond to give the desired chlorosilanes. The hydrolysis of these products, depending on the reaction conditions, gives either silyloxonium chlorides [RSO2-Pro-N(Me)CH2SiMe2OH2]Cl or disiloxanes [RSO2-Pro-N(Me)CH2SiMe2]2O. X-ray diffraction structural analysis showed that the silicon atom in the chlorides and silyloxonium chlorides is pentacoordinated due to an intramolecular O→Si bond and has distorted trigonal-bipyrimidal configuration.29Si NMR spectroscopy showed that the disiloxanes and bicyclic sila-5-piperazinone have a tetracoordinated silicon atom.

Ryanoids and related compounds - Chemoselective electrocatalytic hydrogenation of alkyl α-pyrrole carboxylates: Selective hydrogenation of ryanodine

A study of the electrocatalytic hydrogenation (ECH) process of pyrrote and different alkyl pyrrole-2-carboxylates is presented. Once hydrogenated, the alkyl pyrrole-2-carboxylate becomes an ester of proline, an important natural amino acid. The process is chemoselective to the pyrrole ring. Ryanodine is a natural ryanoid known to be biologically active. The tetrahydroryanodine derivative thus obtained may now represent a molecule of high biological interest. The hydrogenation of ryanodine is possible with electrocatalytic and catalytic processes. In both cases the reaction is not diastereoselective.