56541-07-2

Basic information

• Product Name: 1-(2-FURFURYL)-2-THIOUREA
• Synonyms: 1-(2-FURFURYL)-2-THIOUREA;FURAN-2-YLMETHYL-THIOUREA
• CAS NO: 56541-07-2
• Molecular Formula: C₆H₈N₂OS
• Molecular Weight: 156.21
• Mol File: 56541-07-2.mol

Chemical Properties

• Melting Point: 97-99°C
• Boiling Point: 276.6°C at 760 mmHg
• Flash Point: 121.1°C
• Appearance: /
• Density: 1.274g/cm³
• Vapor Pressure: 0.00475mmHg at 25°C
• Refractive Index: 1.61
• PKA: 13.91±0.70(Predicted)
• CAS DataBase Reference: 1-(2-FURFURYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-FURFURYL)-2-THIOUREA(56541-07-2)
• EPA Substance Registry System: 1-(2-FURFURYL)-2-THIOUREA(56541-07-2)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 56541-07-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-(2-FURFURYL)-2-THIOUREA is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, leveraging its unique chemical structure to create a diverse range of compounds with potential therapeutic and agricultural applications.
Used in Corrosion Inhibition:
In the industry, 1-(2-FURFURYL)-2-THIOUREA is used as a corrosion inhibitor, specifically for metal surfaces that come into contact with aqueous solutions. Its ability to protect metals from corrosion makes it a valuable asset in various industrial applications where metal durability and longevity are crucial.
Used in Pharmaceutical Development:
1-(2-FURFURYL)-2-THIOUREA is used as a precursor in the development of antitumor and antiviral agents. Its potential medicinal applications stem from its unique molecular structure, which allows for the creation of compounds that can target and combat various diseases at the molecular level.
Used in the Chemical Industry:
1-(2-FURFURYL)-2-THIOUREA is utilized in the chemical industry for its diverse applications, including but not limited to the synthesis of pharmaceuticals, agrochemicals, and materials with specific properties, such as corrosion resistance. Its versatility and reactivity make it a key component in the development of new chemical products and processes.

InChI:InChI=1/C6H8N2OS/c7-6(10)8-4-5-2-1-3-9-5/h1-3H,4H2,(H3,7,8,10)

Upstream product

• 4650-60-6 furfuryl isothiocyanate 
• 617-89-0 furan-2-ylmethanamine 
• 333-20-0 potassium thioacyanate 
• 4753-68-8 furan-2-ylmethanamine hydrochloride 

Downstream Products

• 1422363-66-3 C₁₈H₂₃N₅O₅ 
• 1422363-64-1 C₂₅H₃₁N₅O₇ 
• 1320343-38-1 C₂₁H₁₈N₂OS 

Relevant articles and documents

Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase.

The present invention refers to novel substituted aromatic heteroaryl derivatives of formula (I). with the definitions of A, L1, L2, G, J, X and Y according to claim 1. These novel compounds are useful for the inhibition of protein kinases, particularly of the inhibition of Src family protein kinases. Methods for inhibiting kinases by contacting kinases with these novel compounds are disclosed. In another embodiment the present invention refers to pharmaceutical compositions containing these novel compounds and their use for the preparation of medicaments for treating diseases or disorders associated with unphysiological activity of kinases in the body, particularly for the treatment of cancer, immunosuppression, and osteoporosis.

Substituted 5,5′-diphenyl-2-thioxoimidazolidin-4-one as CB 1 cannabinoid receptor ligands: Synthesis and pharmacological evaluation

A set of 30 substituted 5,5′-diphenyl-2-thioxoimidazolidin-4-one (thiohydantoins) derivatives was synthesized, and their affinity for the human CB1 cannabinoid receptor has been evaluated. These compounds are derived from the previously described cannabinoid ligands 5,5′- diphenylimidazolidine-2,4-dione (hydantoins). The replacement of the oxygen by a sulfur leads to an increase of the affinity while the function-i.e., inverse agonism-determined by [35S]-GTPγS experiments remains unaffected. Finally, to evaluate the molecular parameters that could influence the affinity of the thiohydantoins, molecular electrostatic potential as well as lipophilicity calculations were undertaken on representative thiohydantoins and hydantoins derivatives. In conclusion, 5,5′-bis-(4-iodophenyl)-3-butyl-2- thioxoimidazolidin-4-one (31) and 3-allyl-5,5′-bis(4-bromophenyl)-2- thioxoimidazolidin-4-one (32) possess the highest affinity for the CB 1 cannabinoid receptor described to date for the hydantoin and thiohydantoins series when compared in a same bioassay.

Aminothiazoles

A series of 2-aralkylaminothiazoles and the pharmaceutically acceptable acid addition salts thereof having anti-inflammatory and immune regulant activity are disclosed. Preferred compounds include 2-phenethylamino-4-phenyl-thiazole, 2-(p-methoxyphenethylamino)-4-(p-fluorophenyl)-thiazole, 2-phenethylamino-4-phenyl-5-methyl-thiazole, 2-thenylamino-4-phenyl-thiazole and 2-thenylamino-4-(p-fluorophenyl)-thiazole.