565460-58-4Relevant academic research and scientific papers
2-QUINOXALINONE DERIVATIVES AS BRADYKININ ANTAGONISTS AND NOVEL COMPOUNDS
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, (2010/02/10)
2-Quinoxalinone derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.
Discovery of a potent, non-peptide bradykinin B1 receptor antagonist
Su, Dai-Shi,Markowitz, M. Kristine,DiPardo, Robert M.,Murphy, Kathy L.,Harrell, C. Meacham,O'Malley, Stacy S.,Ransom, Richard W.,Chang, Raymond S. L.,Ha, Sookhee,Hess, Fred J.,Pettibone, Douglas J.,Mason, Glenn S.,Boyce, Susan,Freidinger, Roger M.,Bock, Mark G.
, p. 7516 - 7517 (2007/10/03)
Bradykinin (BK) plays an important role in the pathophysiological processes accompanying pain and inflammation. Selective bradykinin B1 receptor antagonists have been shown to be anti-nociceptive in animal models and could be novel therapeutic
