714568-47-5

Upstream product

• 119744-42-2 2-(4-cyanophenyl)ethyl methanesulfonate 
• 80632-27-5 4-Toluenesulfonic acid-2-(4-cyanophenyl)ethyl ester 
• 69395-13-7 4-(2-hydroxyethyl)benzonitrile 

Downstream Products

• 1055983-91-9 ethyl 4-(2-azidoethyl)-benzenecarboximidoate 
• 565460-58-4 N-[2-(4-cyanophenyl)ethyl]-2-{(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetamide 
• 90513-12-5 4‐(2‐aminoethyl)benzamide 
• 714568-42-0 2-[4-(1H-imidazol-2-yl)phenyl]ethanamide 
• 714568-34-0 2-[4-(4,5-dihydro-1H-imidazol-2-yl)-phenyl]-ethylamine 
• 132224-93-2 [(4-cyanophenyl)methyl]methanamine 

Relevant academic research and scientific papers

2-QUINOXALINONE DERIVATIVES AS BRADYKININ ANTAGONISTS AND NOVEL COMPOUNDS

2-Quinoxalinone derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES

Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

NOVEL QUINOXALINONE DERIVATIVES AS BRADYKININ B1 ANTAGONISTS

2-Quinoxalinone derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

KETOPIPERAZINE DERIVATIVES AS BRADYKININ ANTAGONISTS

Ketopiperazine derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.