565468-38-4

Basic information

• Product Name: 2-Propenoic acid, 2-methyl-, 2-[[[2-(benzoyloxy)-5-methylphenoxy]carbonyl]amino]ethyl ester
• CAS NO: 565468-38-4
• Molecular Formula: C21H21NO6
• Molecular Weight: 383.401
• Mol File: 565468-38-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-methyl-, 2-[[[2-(benzoyloxy)-5-methylphenoxy]carbonyl]amino]ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-methyl-, 2-[[[2-(benzoyloxy)-5-methylphenoxy]carbonyl]amino]ethyl ester(565468-38-4)
• EPA Substance Registry System: 2-Propenoic acid, 2-methyl-, 2-[[[2-(benzoyloxy)-5-methylphenoxy]carbonyl]amino]ethyl ester(565468-38-4)

Safety Data

• Hazardous Substances Data: 565468-38-4(Hazardous Substances Data)

Upstream product

• 30674-80-7 2-Isocyanatoethyl methacrylate 
• 65109-84-4 1-benzoyl-4-methylcatechol 

Relevant articles and documents

Synthesis of water-soluble polymeric prodrugs possessing 4-methylcatechol derivatives by mechanochemical solid-state copolymerization and nature of drug release.

In this study we synthesized the water-soluble polymeric prodrugs possessing a 4-methylcatechol (4MC) derivative as a side chain by mechanochemical solid-state copolymerization. 1-benzoyl-4-methylcatechol (Bz4MC) was selected as a model compound of 4MC, and its methacryloyl derivative (1) was synthesized. 6-O-methacryloyl-D-galactose (2) was also prepared as a water-soluble monomer. The mechanochemical solid-state copolymerization of 1 and 2 was carried out to obtain the water-soluble polymeric prodrug possessing the Bz4MC as a side chain. The mechanochemical copolymerization of 1 and 2 proceeded to completion, and the polymeric prodrug produced possessed a narrow molecular weight distribution. Three kinds of polymeric prodrugs, whose compositions were different from one another, were hydrolyzed in vitro. The hydrolysis of these polymeric prodrugs proceeded to completion. The rate constants of hydrolysis decreased with increasing the mole fraction of 1 in polymeric prodrug. It was suggested that the rate constant of hydrolysis could be controlled by the composition, the mole fraction of 1 in the polymeric prodrug.