565470-52-2

Basic information

• Product Name: 2H-Isoindole-2-propanoic acid, 5-[[[2-(1H-benzimidazol-2-yl)ethyl]amino]carbonyl]-1,3-dihydro-1,3-diox o-, phenylmethyl ester
• CAS NO: 565470-52-2
• Molecular Formula: C28H24N4O5
• Molecular Weight: 496.522
• Mol File: 565470-52-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-Isoindole-2-propanoic acid, 5-[[[2-(1H-benzimidazol-2-yl)ethyl]amino]carbonyl]-1,3-dihydro-1,3-diox o-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Isoindole-2-propanoic acid, 5-[[[2-(1H-benzimidazol-2-yl)ethyl]amino]carbonyl]-1,3-dihydro-1,3-diox o-, phenylmethyl ester(565470-52-2)
• EPA Substance Registry System: 2H-Isoindole-2-propanoic acid, 5-[[[2-(1H-benzimidazol-2-yl)ethyl]amino]carbonyl]-1,3-dihydro-1,3-diox o-, phenylmethyl ester(565470-52-2)

Safety Data

• Hazardous Substances Data: 565470-52-2(Hazardous Substances Data)

Upstream product

• 29518-68-1 2-(1H-benzimidazol-2-yl)ethylamine 
• 565470-45-3 2-(2-benzyloxycarbonyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid 
• 552-30-7 trimellitic Anhydride 

Relevant articles and documents

Synthesis of 5-carbonyl-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid integrin antagonists

The 5-carboxy-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid benzyl ester (I), obtained from condensation of 1,3-dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid with β-alanine benzyl ester p-toluenesulfonate, reacted with an appropriate amine (II) to afford the corresponding amide (IIIa-e), which then hydrogenolyzed by 5% palladium-on-carbon to give target compounds (IVa-e).