5656-90-6

Usage

InChI:InChI=1/C12H8O3/c13-11-8-5-1-3-7-4-2-6-9(10(7)8)12(14)15-11/h1-6,11,13H

Upstream product

• 81-84-5 1,8-Naphthalic anhydride 
• 67-56-1 methanol 
• 208-96-8 acenaphthylene 
• 82-86-0 acenaphthene quinone 
• 5811-87-0 1,8-naphthalaldehydic acid 
• 2235-15-6 1(2H)-acenaphthylenone 

Downstream Products

• 5811-87-0 1,8-naphthalaldehydic acid 
• 137282-02-1 (3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(1-oxo-2,3-dihydro-1H-benzisoquinolin-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ester 
• 137282-27-0 (2S)-2-(1-oxo-2,3-dihydro-1H-benzisoquinolin-2-yl)-3-phenylpropionic acid 
• 31553-19-2 3-methoxy-1H,3H-naphtho[1,8-cd]pyran-1-one 

Relevant academic research and scientific papers

Ozonolyses of cycloalkenes in the presence of carbonyl compounds

Ozonolysis reactions of a series of cyclic olefins 1 in the presence of carbonyl compounds 6 provided the corresponding cross-ozonides 42. Further reactions of ozonides 42 with the independently prepared carbonyl oxide +CH2-OO- gave diozonides of structure 43. All of the new ozonides have been isolated as pure substances and characterized by their 1H- and 13C- NMR spectra.

Perilithiation and the synthesis of 8-substituted-1-naphthamides

Attempted perilithiation of 1-naphthamides with their 2-positions blocked leads only to nucleophilic attack on the aromatic ring, but perilithiation of naphthalenes bearing 1-substituents such as -NMe2 or CH2NMe2 allows the synthesis of 8-substituted-1-naphthamldes. The 8- CH2NMe2 substituents can be converted to carbonyl groups by Polonovski reactions; other 8-substituents may be introduced by using naphthalic anhydride as a starting material.

Ring-chain tautomerism. Part 10 +. The reaction of oxocarboxylic acids with diazodiphenylmethane

The rate coefficients for the esterification of a series of oxocarboxylic acids with diazodiphenylmethane have been determined in ethanol or 2-methoxyethanol at 30.0°C. These and the rates of reaction with model compounds have been used to estimate the equilibrium constants for ring-chain tautomerism for the oxocarboxylic acids.

New Modified Heterocyclic Phenylalanine Derivatives. Incorporation into Potent Inhibitors of Human Renin

Modified heterocyclic phenylalanine analogues designed as replacements for the P3-P4 region were synthesized and incorporated into renin inhibitors.These inhibitors were found to have significant activity versus human recombinant renin, as well as in vivo activity.The compounds proved to be very resistant to chymotrypsin degradation, as exemplified by compound 8, which remained greater than 60percent intact after a 24-h exposure to chymotrypsin.In contrast, the Boc-Phe analogue was nearly completely degraded after 1 h.Compound 6 proved to be the most potent renin inhibitor with an IC50=8.9 nM.These stable cyclized phenylalanines should prove to be generally useful as a substitute for Boc-Phe in protease inhibitors.

Synthetic Photochemistry. XVIII. A Sensitizer Dependence in the Photooxidation of Indene and Acenaphthylene. The Occurrence of cis-1,2-Glycol Formation in a Rose Bengal-sensitized Reaction

Upon Rose Bengal-sensitized photooxygenation, indene and acenaphthylene afforded substantial amounts of the expected cis-glycols by means of the reduction of the intermediate dioxetanes.The formerly proposed structure of one of the isomeric methoxy hydroperoxides was revised on the basis of the chemical and spectral evidence.