5656-98-4Relevant academic research and scientific papers
Direct and selective synthesis of 3-arylphthalides via nickel-catalyzed aryl addition/intramolecular esterification
Qiang, Qing,Liu, Feipeng,Rong, Zi-Qiang
supporting information, (2021/05/10)
Herein we report a nickel-catalyzed aryl addition/intramolecular esterification in a cascade fashion. Under the combination of commercially available nickel precursor and tridentate ligand, the one pot protocol offers a direct, simple and regioselective approach to access 3-aryl phthalide derivatives from two readily available substrates with good efficiency, broad scope as well as satisfactory functional group compatibility.
Carboxylate-Directed Addition of Aromatic C-H Bond to Aromatic Aldehydes under Ruthenium Catalysis
Miura, Hiroki,Terajima, Sachie,Shishido, Tetsuya
, p. 6246 - 6254 (2018/06/11)
We report that ruthenium complexes effectively catalyzed the carboxylate-directed addition of aromatic C-H bonds to aldehydes. The reactions of aromatic acids with a variety of aromatic aldehydes including unactivated ones proceeded efficiently to give the corresponding isobenzofuranone derivatives in high yields. The combination of ruthenium(II) complexes with tricyclohexylphosphine led to highly nucleophilic aryl-metal species, which enabled versatile [3 + 2] cycloaddition in the absence of a Lewis acid. This paper also demonstrates the application of supported ruthenium catalysts to the title reaction.
Le lithio-2 naphthalene carbonitrile-1 et ses produits de substitutions
Fraser, R. R.,Savard, S.
, p. 621 - 625 (2007/10/02)
Lithiation of 1-naphthonitrile provides the 2-lithio derivative exclusively.Reaction of this intermediate with ten different electrophiles produces 2-substituted derivatives in moderate to good yields. 2-Alkyl-1-naphthonitriles are readily lithiated and further alkylated to provide alkyl substituents modified at the α position.The pKa values for the hydrogen at the 2-position of 1-cyanonaphthalene and 2-methyl-1-cyanonaphthalene have been determined to be 36.3 and 28.5, respectively.
