5657-22-7Relevant articles and documents
Synthesis and characterization of peroxo complexes of uranium(VI) with some Mannich base ligands
Singh, Balgar,Mahajan, Simpy,Sheikh, Haq N.,Sharma, Mohita,Kalsotra, Bansi L.
experimental part, p. 91 - 99 (2012/08/08)
Uranium(VI) peroxo complexes of composition [UO(O2)L-L(NO 3)2], where L-L are the Mannich base ligands morpholinobenzyl urea, piperidinobenzyl urea, morpholinobenzyl thiourea, piperidinobenzyl thiourea, mor-pholinomethyl thiourea, piperidinomethyl thiourea, or morpholinomethyl urea, are reported. The synthesized complexes were characterized by use of a variety of physi-cochemical techniques, viz. elemental analysis, molar conductivity, magnetic susceptibility measurements, IR, electronic, mass, H NMR, and C NMR spectroscopy, and TGA/DTA studies. These studies revealed that the complexes are both non-electrolytic and diamagnetic in nature. The ligands are bound to the metal in a bidentate mode through carbonyl oxygen or thiocarbonyl sulfur and the ring nitrogen. Mass spectra confirm the molecular mass of the complexes. The antifungal activity of the complexes is greater than that of the corresponding free ligands.
Synthesis and pharmacological evaluation of N'-morpholinomethylurea derivatives with platelet antiaggregant activity
Ribalta,Artus,Salvador,Roma,Vilageliu,Freixes,Bruseghini
, p. 1782 - 1786 (2007/10/02)
In the attempt to prolong and stabilize the known antiaggregant activity of morpholinomethylurea (MMU) derivatives were prepared with carboxylic acids possessing antiaggregant, antiinflammatory or hypolipemic activity. The results of the experiments showed the important anti-aggregant and hypolipemic activity of N-2(p-chlorophenoxy)-isobutyryl-N'-morpholinomethylurea (plafibride, ITA 104). The results obtained seem to indicate that the activity of these new N-acyl-N'-MMU is due initially to the molecule per se although it cannot be totally ruled out that part of the pharmacodynamic effect of the MMU may depend on a prodrug-like behaviour.
