56570-38-8Relevant academic research and scientific papers
Synthesis of N-modified 4-aminopyridine-3-carboxylates by ring transformation
Nishiwaki, Nagatoshi,Nishimoto, Toyosato,Tamura, Mina,Ariga, Masahiro
, p. 1437 - 1439 (2007/10/03)
3-Methyl-5-nitropyrimidin-4(3H)-one reacted with enaminones to cause the ring transformation leading to functionalized 4-aminopyridines. Various kinds of amino groups can be introduced at the 4-position by modifying the enaminones. The modification of its vicinal positions was also possible. In addition, a bicyclic pyridine could be synthesized by making use of the vicinal functionality of a 4-aminopyridine-3-carboxylic acid. Georg Thieme Verlag Stuttgart.
The Reaction of 3-(1-Imidazolyl)-2-alken-1-ones with Nucleophiles
Kashima, C.,Tajima, T.,Shimizu, M.,Omote, Y.
, p. 1325 - 1328 (2007/10/02)
Generally 3-hetero-substituted 2-alken-1-ones were prepared from 1,3-alkanediones, 3-chloro-2-alken-1-ones, or conjugated ynones.The preparation of 3-hetero-substituted 2-alken-1-ones was subjected to some limitations by these methods.By the reaction of 3-(1-imidazolyl)-2-alken-1-ones (I) and 3-(3-oxo-1-alkenyl)-1-methylimidazolium iodides (II) with nucleophiles, 3-hetero-substituted 2-alken-1-ones could be obtained regioselectively in good yield under mild conditions.These results suggested that compounds I and II were concluded to be useful intermediates for the organic synthesis.
