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Usage

Uses

Used in Pharmaceutical Industry:
Carbetapentane is used as a cough suppressant agent for treating cough and cold symptoms. It functions by targeting the cough center in the brain, reducing the urge to cough. 1-(7,7-dioxido-7-thiabicyclo[4.2.0]oct-1-yl)pyrrolidine is often combined with other medications to provide comprehensive relief from respiratory discomfort.
Additionally, carbetapentane is available in various forms such as oral solutions and lozenges, making it a versatile option for healthcare professionals to recommend to patients. It is generally well-tolerated with minimal side effects when used as directed, ensuring patient safety and optimal therapeutic outcomes.

Upstream product

• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 124-63-0 methanesulfonyl chloride 

Relevant academic research and scientific papers

Mechanisms of Hydrolysis of (Trimethylsilyl)methanesulfonyl Chloride. Sulfene-Enamine Reactions in Water

Kinetic, product analysis, and deuteration experiments are consistent with the following mechanisms of hydrolysis of (trimethylsilyl)methanesulfonyl chloride (1) (in 0.01 M KCl at 1 deg C): (a) pH /= 10.0, attack of hydroxide anion (i) at silicon to yield sulfene (5) and (ii) at an α-hydrogen to form (trimethylsilyl)sulfene (4), in each case followed by trapping of the sulfene to give either methanesulfonate (3) or (trimethylsilyl)methanesulfonate (6) salts.Aqueous potassium fluoride catalyzes the hydrolysis of 1 with formation of the methanesulfonate 3, evidently by way of silicophilic attack of fluoride anion on 1 with formation of sulfene (5).Reaction of 1 with an enamine 7 in water (at pH 8 or 9), with or without fluoride, gives two characteristic sulfene-enamine products, (i) the four-membered cycloadduct 8 and (ii) the methylsulfonyl aldehyde 9.The same or related products are also obtained from methanesulfonyl, 2-propanesulfonyl, and phenylmethanesulfonyl chlorides and enamines in water (at pH 9).Hydrolysis of 1 is also catalyzed by aniline or triethylamine evidently giving 5.