5660-66-2

Basic information

• Product Name: 2-Trichloromethyl-1,3-dioxolane
• Synonyms: 2-(Trichloromethyl)-1,3-dioxolane;2-Trichloromethyl-1,3-dioxolane
• CAS NO: 5660-66-2
• Molecular Formula: C₄H₅Cl₃O₂
• Molecular Weight: 191.4403
• Mol File: 5660-66-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 199.9°Cat760mmHg
• Flash Point: 78.9°C
• Appearance: /
• Density: 1.573g/cm³
• Vapor Pressure: 0.471mmHg at 25°C
• Refractive Index: 1.501
• CAS DataBase Reference: 2-Trichloromethyl-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Trichloromethyl-1,3-dioxolane(5660-66-2)
• EPA Substance Registry System: 2-Trichloromethyl-1,3-dioxolane(5660-66-2)

Safety Data

• Hazardous Substances Data: 5660-66-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H5Cl3O2/c5-4(6,7)3-8-1-2-9-3/h3H,1-2H2

Upstream product

• 302-17-0 chloral hydrate 
• 107-21-1 ethylene glycol 
• 75-87-6 chloral 
• 53256-76-1 1,1,1-Trichlor-2-hydroxy-(2-hydroxyethoxy)-ethan 

Downstream Products

• 2612-35-3 2-dichloromethyl-[1,3]dioxolane 
• 4362-56-5 2-(dichloromethylidene)-1,3-dioxolane 
• 851282-74-1 (Z)-2-[1-chloro-2-(4-dimethylaminophenyl)vinyl]-1,3-dioxolane 
• 6425-08-7 4,4'-(phenylmethylene)bismorpholine 

Relevant articles and documents

2-Dichloromethyl-1,3-dioxolan-2-yl orthoesters. A potential protecting group for sugar derivatives

Reactions of 2-dichloromethylene-1,3-dioxolane (2) with acetal protected sugar derivatives in neutral media gave 2-dichloromethyl-1,3-dioxolan-2-yl orthoesters. These orthoesters are readily hydrolysed under mild acidic conditions offering a new method for the preparation of readily removable protecting groups. This strategy was realised in the preparation of 6-O-acetyl-3,5-di-O-methyl-1,2-O-isopropylidene-α-D-glucofuranose.