5660-83-3

Basic information

• Product Name: cyclopentylidenemalononitrile
• Synonyms: cyclopentylidenemalononitrile;2-Cyclopentylidenemalononitrile;Einecs 227-111-9
• CAS NO: 5660-83-3
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16252
• EINECS: 227-111-9
• Mol File: 5660-83-3.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 268.5°C at 760 mmHg
• Flash Point: 124.7°C
• Appearance: /
• Density: 1.126g/cm³
• Vapor Pressure: 0.00765mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: cyclopentylidenemalononitrile(CAS DataBase Reference)
• NIST Chemistry Reference: cyclopentylidenemalononitrile(5660-83-3)
• EPA Substance Registry System: cyclopentylidenemalononitrile(5660-83-3)

Safety Data

• Hazardous Substances Data: 5660-83-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8N2/c9-5-8(6-10)7-3-1-2-4-7/h1-4H2

Upstream product

• 80982-69-0 dicyanomethylene-O,O-diethyl phosphorane 
• 120-92-3 cyclopentanone 
• 1192-28-5 Cyclopentanone oxime 
• 109-77-3 malononitrile 

Downstream Products

• 141811-22-5 5-Amino-7-(4-nitro-phenyl)-indan-4,6-dicarbonitrile 
• 10432-35-6 1,1,2,2-tetracyano-3,3-tetramethylenecyclopropane 
• 21369-33-5 6'-amino-3',3'a,4',5'-tetrahydrospiro[cyclopentane-1,4'(2'H)-indene]-5',5',7'-tricarbonitrile 
• 70291-62-2 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile 
• 129224-52-8 6'-amino-3',5'-dicyano-1',4'-dihydro-spiro-2'-thione 
• 103589-67-9 3-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile 
• 144296-08-2 3-Thioxo-1-p-tolyl-3,5,6,7-tetrahydro-2H-[2]pyrindine-4-carbonitrile 
• 144296-35-5 1-(4-Methoxy-phenyl)-3-oxo-3,5,6,7-tetrahydro-2H-[2]pyrindine-4-carbonitrile 
• 144296-34-4 3-Oxo-1-p-tolyl-3,5,6,7-tetrahydro-2H-[2]pyrindine-4-carbonitrile 
• 144296-07-1 1-(4-Chloro-phenyl)-3-oxo-3,5,6,7-tetrahydro-2H-[2]pyrindine-4-carbonitrile 
• 144296-29-7 3-Chloro-1-(4-methoxy-phenyl)-6,7-dihydro-5H-[2]pyrindine-4-carbonitrile 
• 144296-28-6 3-Chloro-1-p-tolyl-6,7-dihydro-5H-[2]pyrindine-4-carbonitrile 
• 144296-06-0 3-Chloro-1-(4-chloro-phenyl)-6,7-dihydro-5H-[2]pyrindine-4-carbonitrile 
• 144296-02-6 [1-Amino-5-(4-methoxy-phenyl)-7,8-dihydro-6H-cyclopenta[d]thieno[2,3-b]pyridin-2-yl]-phenyl-methanone 

Relevant articles and documents

Asymmetric organocatalytic vinylogous Michael addition triggered triple-cascade reactions of 2-hydroxycinnamaldehydes and vinylogous nucleophiles: construction of benzofused oxabicyclo[3.3.1]nonane scaffolds

An organocatalytic vinylogous Michael addition triggered triple-cascade reaction has been developed. 2-Hydroxycinnamaldehydes worked under iminium activation with either acyclic or cyclic ketone-derived α,α-dicyanoalkenes, yielding the benzofused oxabicyclo[3.3.1]nonanes bearing one quaternary stereocenter with excellent stereoselectivities.

Method used for preparing substituted 1, 3-malononitrile

The invention belongs to the field of fine chemical product preparation and medicine intermediate synthesis, and relates to a method used for preparing substituted 1, 3-malononitrile. According to themethod, an aldehyde or a ketone and malononitrile are subjected to condensation reaction to prepare substituted 1, 3-malononitrile, wherein water is taken as a solvent, the aldehyde or the ketone andmalononitrile are subjected to Knoevenagel condensation under catalytic effect of zinc proline so as to obtain the corresponding substituted 1, 3-malononitrile. The method conditions are mild; operation is convenient; water is taken as a reaction solvent, so that the method is friendly to the environment; and the application prospect is promising.

Amino Acid Amide based Ionic Liquid as an Efficient Organo-Catalyst for Solvent-free Knoevenagel Condensation at Room Temperature

Abstract: Ionic liquids of amino acid amide were synthesized and used as an efficient catalyst for solvent-free Knoevenagel condensation. Synthesized ionic liquids are an environmentally benign, inexpensive, metal free and plays the dual role of solvent as well as an efficient catalyst for Knoevenagel condensation. A wide range of aliphatic, aromatic and heteroaromatic aldehydes easily undergo condensation with malononitrile and ethyl cyanoacetate. The reaction proceeds at room temperature without using any organic solvent and is very fast with good to excellent yield. Additionally, the catalyst is easily separable and recyclable without loss of activity. Graphic Abstract: [Figure not available: see fulltext.].