56614-75-6Relevant academic research and scientific papers
'Higher-order' azomethine ylides in the synthesis of functionalized pyrroles and 5-oxo-5H-pyrrolizines
Pinho e Melo, Teresa M.V.D.,Soares, Maria I.L.,Nunes, Cláudio M.
, p. 1833 - 1841 (2007/10/03)
Azafulvenium methides generated by the thermal extrusion of SO2 from 1-methyl- and 1,1-dimethyl-1H,3H-pyrrolo[1,2-c]thiazole-2,2-dioxides undergo [1,8]H sigmatropic shifts to give vinylpyrroles. Flash vacuum pyrolysis of the C-vinylpyrroles affords 5-oxo-5H-pyrrolizines or C-allyl-1H-pyrroles.
Anti-tumor compositions containing the reactive product of benzaldehyde or salicylaldehyde with penicillamine and method of use thereof
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, (2008/06/13)
A composition for therapy of tumors having high tyrosinase activity contains the reaction product of penicillamine with a cytotoxic aldehyde, or pharmaceutically acceptable salts or esters thereof, and a pharmaceutically acceptable vehicle. The preferred compounds are 5,5-dimethyl-2-phenyl-4-thiazolidine carboxylic acid or 5,5-dimethyl-2-(2-hydroxyphenyl)-4-thiazolidine carboxylic acid, or pharmaceutically acceptable salts or esters thereof. Treatment preferably comprises an intra-arterial drip. Diagnosis of tumors suitable for treatment by means of these compositions may be accomplished by administering a radioactive copper salt and scanning for accumulations of radioactivity. This will indicate sites of high tyrosinase activity.
2-Phenyl thiazolidine derivatives as radioprotective agents
Terol,Fernandez,Robbe,et al.
, p. 149 - 151 (2007/10/04)
31 derivatives of 2-phenyl thiazolidine were submitted to radio-pharmacological tests on mice. They usually present little toxicity and some of them show a rather interesting activity.
