56618-03-2Relevant articles and documents
Synthesis of a Phosphinic Acid Transition State Analogue Inhibitor of Dihydroorotase
Cao, Yu,Christopherson, Richard I.,Elix, John A.,Gaul, Kim L.
, p. 903 - 912 (2007/10/02)
The synthesis of the phosphinic acid 4-hydroxy-6-oxo-1,4-azaphosphinane-2-carboxylic acid 4-oxide (11) is described.The phosphinic acid (11) was designed as a transition state analogue inhibitor of dihydroorotase.
Synthesis of 6-Phosphonoalkyl Tetrahydro-4-pyrimidinecarboxylic Acids as NMDA Receptor Antagonists
Bigge, Christopher F.,Wu, Jiang-Ping,Drummond, James R.
, p. 7659 - 7662 (2007/10/02)
The title compounds were prepared via a sequence which involved as the key steps a Michael reaction between nitroalkyl phosphonates and protected dehydroalanine and subsequent cyclization of the α,γ-diamino esters.Key Words: 6-phosphonoalkyl tetrahydro-4-
SYNTHESIS OF LACTIVICIN ANALOGUES
Tamura, Norikazu,Matsushita, Yoshihiro,Yoshioka, Kouichi,Ochiai, Michihiko
, p. 3231 - 3240 (2007/10/02)
Aza analogues of lactivicin (1), a recently discovered novel antibiotic, were prepared by an application of our earlier convenient synthesis of 1 and its derivatives.A 1-unsubstituted pyrazolidinone derivative bearing 2-aminothiazol-4-yl-(Z)-methoxyiminoa