56410-68-5Relevant academic research and scientific papers
NOVEL 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
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Paragraph 1000, (2014/12/09)
The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
Structural determinants of substrates and inhibitors: Probing glutamate transporters with 2,4-methanopyrrolidine-2,4-dicarboxylate
Esslinger, C. Sean,Koch, Hans P.,Kavanaugh, Michael P.,Philips, Dean P.,Chamberlin, A. Richard,Thompson, Charles M.,Bridges, Richard J.
, p. 3101 - 3106 (2007/10/03)
Using an intramolecular [2+2] photocyclization, 2,4-methanopyrrolidine- 2,4-dicarboxylate was prepared as a conformationally locked analogue of glutamate. This compound, in combination with two other pyrrolidine dicarboxylates, has been used to define the structural elements that differentiate substrate and nonsubstrate inhibitors of a high-affinity, sodium-dependent glutamate transporter.
Synthesis of 6-Phosphonoalkyl Tetrahydro-4-pyrimidinecarboxylic Acids as NMDA Receptor Antagonists
Bigge, Christopher F.,Wu, Jiang-Ping,Drummond, James R.
, p. 7659 - 7662 (2007/10/02)
The title compounds were prepared via a sequence which involved as the key steps a Michael reaction between nitroalkyl phosphonates and protected dehydroalanine and subsequent cyclization of the α,γ-diamino esters.Key Words: 6-phosphonoalkyl tetrahydro-4-
