566203-06-3Relevant academic research and scientific papers
Total synthesis of (-)-ephedradine A: An efficient construction of optically active dihydrobenzofuran-ring via C-H insertion reaction
Kurosawa, Wataru,Kobayashi, Hideki,Kan, Toshiyuki,Fukuyama, Tohru
, p. 9615 - 9628 (2007/10/03)
The stereocontrolled total synthesis of (-)-ephedradine A (1) has been accomplished. Construction of optically active dihydrobenzofuran-ring was performed by a novel asymmetric C-H insertion reaction. After an intramolecular ester-amide exchange reaction and a Sharpless asymmetric aminohydroxylation reaction, construction of the complex macrocyclic ring was performed by Ns-strategy and an intramolecular aza-Wittig reaction. Graphical Abstract.
Stereocontrolled total synthesis of (-)-ephedradine a (orantine)
Kurosawa, Wataru,Kan, Toshiyuki,Fukuyama, Tohru
, p. 8112 - 8113 (2007/10/03)
The stereocontrolled total synthesis of (-)-ephedradine A has been accomplished. The synthesis features an asymmetric C-H insertion reaction, an intramolecular ester-amide exchange reaction, and a Sharpless asymmetric aminohydroxylation reaction. Construction of the complex macrocyclic ring was performed by Ns-strategy and an intramolecular aza-Wittig reaction. Copyright
