5663-61-6

Basic information

• Product Name: Benzeneacetamide, N-(2-oxoethyl)-
• CAS NO: 5663-61-6
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Mol File: 5663-61-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzeneacetamide, N-(2-oxoethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetamide, N-(2-oxoethyl)-(5663-61-6)
• EPA Substance Registry System: Benzeneacetamide, N-(2-oxoethyl)-(5663-61-6)

Safety Data

• Hazardous Substances Data: 5663-61-6(Hazardous Substances Data)

Usage

General Description

Benzeneacetamide, N-(2-oxoethyl)- is a chemical compound that belongs to the class of benzene derivatives. It is also known as N-(2-acetylphenyl) acetamide. It is a white crystalline solid with a slightly sweet odor. This chemical is commonly used as an intermediate in the production of pharmaceuticals and other organic compounds. It is also used as a flavoring agent in the food industry. However, benzeneacetamide, N-(2-oxoethyl)- is considered to be a hazardous chemical and should be handled with care due to its potential health and environmental risks.

Upstream product

• 103-80-0 phenylacetyl chloride 
• 722479-69-8 phenyl-acetic acid-(2,2-diethoxy-ethylamide) 
• 54-35-3 penicillin G procaine 

Downstream Products

• 101285-70-5 phenyl-acetic acid-[2-(2,4-dinitro-phenylhydrazono)-ethylamide] 
• 371143-27-0 1-(2-benzoxazolyl)-2-(phenylacetylamino)ethanol 
• 371143-07-6 N-(2-benzooxazol-2-yl-2-oxo-ethyl)-2-phenyl-acetamide 
• 371143-24-7 phenylacetylaminoacetaldehyde cyanohydrin 

Relevant articles and documents

Design, synthesis, and evaluation of α-ketoheterocycles as class C β-lactamase inhibitors

A series of specific α-ketoheterocycles (benzoxazole, thiazole, imidazole, tetrazole, and thiazole-4-carboxylate) has been synthesized in order to assess their potential as β-lactamase inhibitors. The syntheses were achieved either by construction of the heterocycle (benzoxazole) from an appropriate α-hydroxyimidate, followed by oxidation of the alcohol, or by direct reaction of methyl phenaceturate with a lithiated heterocycle. The properties of these compounds in aqueous solution are described and their inhibitory activity against β-lactamases assessed. They did inhibit the class C β-lactamase of Enterobacter cloacae P99 but not the TEM β-lactamase. The most effective inhibitor of the former enzyme (Ki = 0.11 mM) was 5-(phenylacetylglycyl) tetrazole, probably because it is an anion at neutral pH. Interpretation of the results was aided by computational models of the tetrahedral adducts. Most of the compounds also inhibited α-chymotrypsin but not porcine pancreatic elastase.