722479-69-8

Basic information

• Product Name: phenyl-acetic acid-(2,2-diethoxy-ethylamide)
• CAS NO: 722479-69-8
• Molecular Weight: 251.326
• Mol File: 722479-69-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: phenyl-acetic acid-(2,2-diethoxy-ethylamide)(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl-acetic acid-(2,2-diethoxy-ethylamide)(722479-69-8)
• EPA Substance Registry System: phenyl-acetic acid-(2,2-diethoxy-ethylamide)(722479-69-8)

Safety Data

• Hazardous Substances Data: 722479-69-8(Hazardous Substances Data)

Upstream product

• 645-36-3 2,2-diethoxy-ethanamine 
• 103-80-0 phenylacetyl chloride 
• 103-81-1 Benzeneacetamide 

Downstream Products

• 371143-27-0 1-(2-benzoxazolyl)-2-(phenylacetylamino)ethanol 
• 371143-07-6 N-(2-benzooxazol-2-yl-2-oxo-ethyl)-2-phenyl-acetamide 
• 371143-24-7 phenylacetylaminoacetaldehyde cyanohydrin 
• 5663-61-6 phenylacetylaminoacetaldehyde 
• 89314-92-1 (2Ξ,4S)-2-[(2-phenyl-acetylamino)-methyl]-thiazolidine-4-carboxylic acid 
• 146655-31-4 (4R)-5,5-dimethyl-2c-[(2-phenyl-acetylamino)-methyl]-thiazolidine-4r-carboxylic acid 
• 73184-15-3 (4R)-5,5-dimethyl-2t-[(2-phenyl-acetylamino)-methyl]-thiazolidine-4r-carboxylic acid 
• 89314-92-1 (2Ξ,4R)-2-[(2-phenyl-acetylamino)-methyl]-thiazolidine-4-carboxylic acid 
• 73184-06-2 (5R,3S)-benzyl-D-penilloic acid 
• 63696-24-2 (5S,3S)-benzyl-D-penilloic acid 

Relevant articles and documents

Design, synthesis, and evaluation of α-ketoheterocycles as class C β-lactamase inhibitors

A series of specific α-ketoheterocycles (benzoxazole, thiazole, imidazole, tetrazole, and thiazole-4-carboxylate) has been synthesized in order to assess their potential as β-lactamase inhibitors. The syntheses were achieved either by construction of the heterocycle (benzoxazole) from an appropriate α-hydroxyimidate, followed by oxidation of the alcohol, or by direct reaction of methyl phenaceturate with a lithiated heterocycle. The properties of these compounds in aqueous solution are described and their inhibitory activity against β-lactamases assessed. They did inhibit the class C β-lactamase of Enterobacter cloacae P99 but not the TEM β-lactamase. The most effective inhibitor of the former enzyme (Ki = 0.11 mM) was 5-(phenylacetylglycyl) tetrazole, probably because it is an anion at neutral pH. Interpretation of the results was aided by computational models of the tetrahedral adducts. Most of the compounds also inhibited α-chymotrypsin but not porcine pancreatic elastase.