56632-74-7

Basic information

• Product Name: 6-O-benzoyl-3-deoxy-3-fluoro-1,2-O-isopropylidene-alpha-D-glucofuranose
• Synonyms: 6-O-benzoyl-3-deoxy-3-fluoro-1,2-O-isopropylidene-alpha-D-glucofuranose
• CAS NO: 56632-74-7
• Molecular Formula: C₁₆H₁₉FO₆
• Molecular Weight: 326.3168632
• Mol File: 56632-74-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 436.4°C at 760 mmHg
• Flash Point: 217.7°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 2.18E-08mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: 6-O-benzoyl-3-deoxy-3-fluoro-1,2-O-isopropylidene-alpha-D-glucofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 6-O-benzoyl-3-deoxy-3-fluoro-1,2-O-isopropylidene-alpha-D-glucofuranose(56632-74-7)
• EPA Substance Registry System: 6-O-benzoyl-3-deoxy-3-fluoro-1,2-O-isopropylidene-alpha-D-glucofuranose(56632-74-7)

Safety Data

• Hazardous Substances Data: 56632-74-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H19FO6/c1-16(2)22-13-11(17)12(21-15(13)23-16)10(18)8-20-14(19)9-6-4-3-5-7-9/h3-7,10-13,15,18H,8H2,1-2H3/t10-,11+,12-,13-,15-/m1/s1

Upstream product

• 18530-81-9 (R)-1-((3aR,5R,6S,6aS)-6-fluoro-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethane-1,2-diol 
• 98-88-4 benzoyl chloride 
• 14049-05-9 3-deoxy-1,2;5,6-di-O-isopropylidene-3-fluoro-α-D-glucofuranose 
• 208525-43-3 1,2:5,6-di-O-isopropylidene-3-O-(N-imidazole-1-sulfonyl)-α-D-allofuranose 
• 2595-05-3 Diacetone D-glucose 

Downstream Products

• 1030022-54-8 3-deoxy-3-fluoro-6-O-benzoyl-1,2-O-isopropylidene-5-O-methanesulfonyl-α-D-glucofuranose 

Relevant articles and documents

SOLID FORM OF 4'-THIO-2'-FLUORONUCLEOSIDE PHOSPHAMIDE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to a solid form of a compound of Formula (I), a method for preparing the solid form, a pharmaceutical composition comprising the solid form, and the use of the solid form in the treatment of a disease involving abnormal cell proliferation or a viral infectious disease.

An alternative synthesis of antineoplastic 4'-thiocytidine analogue 4'- thioFAC

We have developed an alternative method for the synthesis of 2'-modified 4'-thionucleosides. The fusion of 3,5-di-O-benzoyl-1-bromo-2-deoxy-2-fluoro- 4-thio-α-D-arabinofuranose, prepared from 1,2:5,6-diisopropylidene-α-D- allofuranose, with persilylated N4-acetylcytosine predominantly gave a β- anomer of protected 4'-thionucleoside, which was then deprotected to give 4'- thioFAC.