56643-93-7Relevant academic research and scientific papers
Palladium-Catalyzed Dehydrative Cross-Coupling of Allylic Alcohols and N-Heterocycles Promoted by a Bicyclic Bridgehead Phosphoramidite Ligand and an Acid Additive
Kang, Kyungjun,Kim, Jaewook,Lee, Ansoo,Kim, Woo Youn,Kim, Hyunwoo
supporting information, p. 616 - 619 (2016/02/18)
A mild and efficient dehydrative cross-coupling reaction between allylic alcohols and N-heterocycles using palladium catalysis is reported. A bicyclic bridgehead phosphoramidite (briphos) ligand together with Pd(dba)2 is a highly efficient catalyst, and an acid additive involved in the rate-determining step promotes the catalytic cycle. The coupling reaction of allylic alcohols with N-heterocycles including imidazoles, benzimidazoles, and triazole proceeds under mild reaction conditions with high yields using Pd/briphos and pentafluorophenol.
Palladium-catalyzed amination of allyl alcohols
Ghosh, Raju,Sarkar, Amitabha
experimental part, p. 8508 - 8512 (2011/12/04)
An efficient catalytic amination of aryl-substituted allylic alcohols has been developed. The complex [(η3-allyl)PdCl]2 modified by a bis phosphine ligand, L, has been used as catalyst in the reaction that afforded a wide range of allyl amines in good to excellent yield under mild conditions.
Design and synthesis of 3-(azol-1-yl)phenylpropanes as microbicidal spermicides for prophylactic contraception
Kumar, Lalit,Sarswat, Amit,Lal, Nand,Jain, Ashish,Kumar, Sumit,Kiran Kumar,Maikhuri, Jagdamba P.,Pandey, Atindra K.,Shukla, Praveen K.,Gupta, Gopal,Sharma, Vishnu L.
supporting information; experimental part, p. 176 - 181 (2011/02/27)
We designed a series of 25 3-(azol-1-yl)phenylpropanes which yielded 10 compounds (3, 4, 7, 8, 13, 14, 19, 21, 23, 26) that irreversibly immobilized 100% human sperm at 1% (w/v) concentration in 60 s; 12 compounds (8, 9, 15, 16, 19-21, 23-25, 27, 28) that showed potent microbicidal activity at 12.5-50 μg/mL against Trichomonas vaginalis; and 17 compounds (3-11, 13, 15, 19, 21, 23, 26, 28, 30) that exhibited potent anticandida activity with minimum inhibitory concentration (MIC) of 12.5-50 μg/mL. Almost all the compounds exhibited high level of safety towards normal vaginal flora (Lactobacillus) and human cervical (HeLa) cells in comparison to the marketed spermicide nonoxynol-9 (N-9). All the biological activities were evaluated in vitro. Two compounds (4, 8) with good safety profile exhibited multiple (spermicidal, antitrichomonas and anticandida) activities, warranting further lead optimization for furnishing a prophylactic vaginal contraceptive.
