56649-48-0

Basic information

• Product Name: (R)-(+)-1-(1-PHENYLETHYL)-1H-IMIDAZOLE-5-CARBOXYLIC ACID
• Synonyms: 1H-IMIDAZOLE-5-CARBOXYLIC ACID, 1-(1-PHENYLETHYL)-, (R)-;1H-IMIDAZOLE-5-CARBOXYLIC ACID, 1-[(1R)-1-PHENYLETHYL]-;(R)-DESETHYL-ETOMIDATE;(R)-(+)-1-(1-PHENYLETHYL)-1H-IMIDAZOLE-5-CARBOXYLIC ACID;R28141;1-((1R)-1-Phenylethyl)-1H-iMidazole-5-carboxylic Acid;1-(1R)-(1-Phenylethyl)-1H-iMidazole-5-carboxylic Acid;1-[(1R)-1-Phenylethyl]-1H-iMidazole-5-carboxylic Acid
• CAS NO: 56649-48-0
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.24
• Product Categories: Metaboliites & Impurities;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 56649-48-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 156.3 °C
• Boiling Point: 437.5±20.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• PKA: 2.29±0.36(Predicted)
• CAS DataBase Reference: (R)-(+)-1-(1-PHENYLETHYL)-1H-IMIDAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1-(1-PHENYLETHYL)-1H-IMIDAZOLE-5-CARBOXYLIC ACID(56649-48-0)
• EPA Substance Registry System: (R)-(+)-1-(1-PHENYLETHYL)-1H-IMIDAZOLE-5-CARBOXYLIC ACID(56649-48-0)

Safety Data

• Hazardous Substances Data: 56649-48-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

Uses

Etomidate Acid is a metabolite and carboxylic acid analogue of the short-acting hypnotic drug, Etomidate (E933310).

Upstream product

• 33125-97-2 etomidate 
• 53188-20-8 Etomidate hydrochloride 
• 61045-91-8 (R)-Metomidate 

Downstream Products

• 1198154-79-8 MOC-(R)-etomidate hydrochloride 
• 960403-10-5 2-hydroxyethyl 3-[(1R)-1-phenylethyl]imidazole-4-carboxylate 

Relevant articles and documents

2-(3-Methyl-3H-diaziren-3-yl) ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: A derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels

To locate general anesthetic binding sites on ligand-gated ion channels, a diazirine derivative of the potent intravenous anesthetic, R-(+)-etomidate (2-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate), has been synthesized and characterized. R-(+)-Azi

Ketone-substituted heterocyclic compound and anesthetic effect thereof

The invention discloses a ketone-substituted heterocyclic compound and an anesthetic effect thereof. Specifically provided are a compound represented by formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, or a deuterated derivative thereof. The ketone-substituted heterocyclic compound provided by the invention has a good central nervous system inhibition effect, can generate sedative, hypnotic and/or general anesthesia effects, and can control the epilepsy persistent state; the ketone-substituted heterocyclic compound also has the characteristics of quick response and quick recovery while maintaining excellent anesthetic activity; meanwhile, the ketone-substituted heterocyclic compound has almost no inhibition effect on the adrenal cortex function, has small sideeffects, solves the technical problems in the field, and provides a new choice for clinically screening and/or preparing sedative, hypnotic and/or general anesthesia medicines and medicines for controlling the epilepsy persistent state.

Phenylethyl imidazole derivative and application thereof

The invention belongs to the technical field of medicines, and provides a novel phenylimidazole amide derivative shown as a general formula (I) (See the specification) and a geometrical isomer or pharmaceutically acceptable salt, hydrate, solvate and prodrug thereof, and preparation methods thereof. The compound can activate the activity of TGR5 and can be used for treating or preventing diseasesrelated to TGR5 activity regulation.