56653-44-2

Basic information

• Product Name: Ethanone, 2-bromo-1-[1-(phenylmethyl)-1H-benzimidazol-2-yl]-
• CAS NO: 56653-44-2
• Molecular Formula: C16H13BrN2O
• Molecular Weight: 329.196
• Mol File: 56653-44-2.mol

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-bromo-1-[1-(phenylmethyl)-1H-benzimidazol-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-bromo-1-[1-(phenylmethyl)-1H-benzimidazol-2-yl]-(56653-44-2)
• EPA Substance Registry System: Ethanone, 2-bromo-1-[1-(phenylmethyl)-1H-benzimidazol-2-yl]-(56653-44-2)

Safety Data

• Hazardous Substances Data: 56653-44-2(Hazardous Substances Data)

Upstream product

• 56653-41-9 1-(1-benzyl-1H-benzo[d]imidazol-2-yl)ethan-1-one 
• 16414-04-3 1-benzimidazol-2-ylethanol 
• 939-70-8 2-acetylbenzimidazole 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

One-pot synthesis of 2-(1-alkyl/aralkyl-1H-benzimidazole-2-yl)-quinoxaline derivatives using molecular iodine

The title compound (5) has been prepared in one pot by refluxing 1-(1-alkyl/aralkyl-1H-benzimidazole-2-yl)-ethanone (1) with substituted o-phenylenediamine (2) in ethanol in the presence of iodine. Alternatively, 5 could also be prepared by treating 2-bromo-1-(1- alkyl/aralkyl-1H-benzimidazole- 2-yl)-ethanone (3A) with 2 in refluxing ethanol. The formation of 5 from 1 and 2 probably occurs through the intermediacy of 3B (i.e., 3, X=I) and 4. Copyright Taylor & Francis Group, LLC.

Studies on syntheses of 1-alkyl-2-substitutedthiazolylbenzimidazoles

Studies on syntheses of 1-alkyl-2-substitutedthiazolylbenzimidazoles 4 starting from 2-acetylbenzimidazoles 1 have been reported. Alkylation of 1 leads to 1-alkyl-2-acetylbenzimidazoles 2, which on bromination yield the known 1-alkyl-2-(α-bromoacetyl)benz

An unusual resistance to α-bromination by arylacetyl compound: Studies on bromination of 2-acetylbenzimidazoles and their subsequent reactions with sulphur nucleophiles - Synthesis of novel β-ketosulphone derivatives of benzimidazoles

Condensation of o-phenylenediamine with lactic acid under Phillips' conditions gave the known 2(α-hydroxyethyl)benzimidazole 1 which on oxidation with acid dichromate furnishes 2-acetylbenzimidazole 2. Reaction of 2 with bromine in acetic acid at room temp. give a novel product 3 but not the expected 2-(α-bromoacetyl)benzimidazole 4. Rational explanation is offered for this anamolous behaviour of 2. Compound 2 on alkylation, give 1- alkyl derivatives which undergo smooth bromination with bromine in acetic acid to give the corresponding 1-alkyl-2(α-bromoacetyl)benzimidazoles. Reactions of latter with sulphur nucleophiles such as PhS-, ArSO2- etc., resulting in substitution of bromine, leading to novel β-ketosulphone derivatives of benzimidazoles, are reported. Products have been characterised by IR, NMR (1H and 13C) and mass spectral data.