566938-27-0

Upstream product

• 18138-86-8 (furan-2-yl)methyl triphenylphosphonium bromide 
• 391678-31-2 (2R)-tert-butoxycarbonylamino-3-n-hexanoyloxy-2-ethyl-1-propanol 
• 391678-38-9 (2S)-tert-butoxycarbonylamino-2-ethyl-3-n-hexanoyloxy-1-propanal 
• 391678-52-7 2-((tert-butoxycarbonyl)amino)-2-ethyl-1,3-propanediol 
• 566938-21-4 (2R)-tert-butoxycarbonylamino-2-ethyl-1-n-hexanoyloxy-4-(furan-2-yl)-3-butene 

Downstream Products

• 566938-31-6 (4R)-ethyl-4-[2-(furan-2-yl)ethyl]-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

Asymmetric synthesis of α,α-disubstituted α-amino alcohol derivatives

We herein report an asymmetric synthesis of α,α-disubstituted α-amino alcohol derivatives 3, key intermediates of a novel immunomodulator, using enzymatic desymmetrization of 2-alkyl-2-tert-butoxycarbonylamino-1,3-propanediols 1a and 1b. This method makes

AMINO ALCOHOL DERIVATIVE OR PHOSPHONIC ACID DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THESE

The present invention relates to amino alcohol derivatives or phosphonic acid derivatives having excellent immunosuppressive activity, pharmacologically acceptable salts thereof or pharmacologically acceptable esters thereof, and to pharmaceutical compositions comprising said compounds as an active ingredient: [wherein, ???R1 and R2 each represent a hydrogen atom, or a protecting group of the amino group; ???R3 represents a hydrogen atom, or a protecting group of the hydroxyl group; ???R4 represents a lower alkyl group; ???n represents an integer of from 1 to 6; ???X represents an oxygen atom or a nitrogen atom unsubstituted or substituted with a lower alkyl group or the like; ???Y represents an ethylene group; ???Z represents a C1-C10 alkylene group; ???R5 represents an aryl group, or an aryl group substituted with substituents; ???R6 and R7 each represents a hydrogen atom; provided that when R5 represents a hydrogen atom, then Z represents a group other than a single bond or a straight chain C1-C10 alkylene group] .