566943-98-4Relevant academic research and scientific papers
2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER
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Paragraph 0522; 0523, (2013/05/08)
The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particu
2,4- DIARYL-SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER
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Page/Page column 117, (2012/01/14)
The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases playsa role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors
Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors
Chen, Ping,Norris, Derek,Haslow, Kristin D.,Dhar, T. G. Murali,Pitts, William J.,Watterson, Scott H.,Cheney, Daniel L.,Bassolino, Donna A.,Fleener, Catherine A.,Rouleau, Katherine A.,Hollenbaugh, Diane L.,Townsend, Robert M.,Barrish, Joel C.,Iwanowicz, Edwin J.
, p. 1345 - 1348 (2007/10/03)
Screening of our in-house compound collection led to the discovery of 5-bromo-6-amino-2-isoquinoline 1 as a weak inhibitor of IMPDH. Subsequent optimization of 1 afforded a series of novel 2-isoquinolinoaminooxazole-based inhibitors, represented by 17, with single-digit nanomolar potency against the enzyme.
