23687-26-5

Basic information

• Product Name: 6-AMINOISOQUINOLINE
• Synonyms: 6-AMINOISOQUINOLINE;6-aminoisoquanoline;6-Isoquinolinamine;Isoquinoline-6-amine;Isoquinolin-6-ylamine;Isoquinolin-6-amine, 6-Amino-2-azanaphthalene;Isoquinoline,6-amino- (7CI,8CI)
• CAS NO: 23687-26-5
• Molecular Formula: C₉H₈N₂
• Molecular Weight: 144.17
• EINECS: -0
• Product Categories: Building Blocks;Isoquinoline
• Mol File: 23687-26-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 211-212 °C(Solv: benzene (71-43-2))
• Boiling Point: 343.1 °C at 760 mmHg
• Flash Point: 188.1 °C
• Appearance: /
• Density: 1.21 g/cm³
• Vapor Pressure: 7.2E-05mmHg at 25°C
• Refractive Index: 1.708
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.10±0.10(Predicted)
• CAS DataBase Reference: 6-AMINOISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINOISOQUINOLINE(23687-26-5)
• EPA Substance Registry System: 6-AMINOISOQUINOLINE(23687-26-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 23687-26-5(Hazardous Substances Data)

Usage

Uses

6-Aminoisoquinoline is a reactant used in the preparation of N-[{2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)-pyridin-3-yl}methyl] N''-(6,6-fused heterocyclic) ureas as highly potent TRPV1 antagonists.

InChI:InChI=1/C9H8N2/c10-9-2-1-8-6-11-4-3-7(8)5-9/h1-6H,10H2

Upstream product

• 7651-82-3 isoquinolin-6-ol 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 52962-35-3 2-(1,3-diethoxy-1,3-dioxopropan-2-yl)-4-nitrobenzoic acid 
• 99-60-5 2-chloro-4-nitrobenzoic acid 
• 39585-32-5 2-carboxymethyl-4-nitro-benzoic acid 
• 1082674-24-5 6-(bromoisoquinoline-1-carbonitrile) 
• 76144-87-1 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl 
• 34784-05-9 6-bromo-isoquinoline 
• 1336-21-6 ammonium hydroxide 
• 70538-57-7 6-nitroisoquinoline 

Downstream Products

• 566944-05-6 N-isoquinolin-6-yl-acetamide 
• 566943-98-4 5-bromo-isoquinolin-6-ylamine 
• 566943-99-5 5-chloro-6-aminoisoquinoline 
• 72299-67-3 1,2,3,4-tetrahydroisoquinolin-6-amine 
• 107322-01-0 isoquinoline-6-sulfonyl chloride 

Relevant articles and documents

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Methods for the preparation of 6-aminoisoquinoline

Described are methods for the preparation of 6-aminoisoquinoline, a useful intermediate compound in the synthesis of kinase inhibitors.

Solid supported rhodium(0) nanoparticles: An efficient catalyst for chemo- and regio-selective transfer hydrogenation of nitroarenes to anilines under microwave irradiation

A Solid-supported rhodium(0) (SS-Rh) catalyst has been developed and applied for the chemo- and regio-selective reduction of nitroarenes functionalized with CC multiple bonds and dinitroarenes to their corresponding amines respectively using hydrazine hydrate (N2H4· H2O) as a reducing source under mild microwave irradiation (MWI) conditions. The present methodology also shows excellent compatibility with a broad range of structurally diverse reducible functional groups. The catalyst can be recovered by simple filtration and reused for 13 cycles with consistent activity hence reduces the cost of the catalyst assertively.