56703-36-7Relevant academic research and scientific papers
Novel 6-5 fused ring heterocycle antifolates with potent antitumor activity: Bridge modifications and heterocyclic benzoyl isosters of 2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine antifolate
Kotake,Okauchi,Iijima,Yoshimatsu,Nomura
, p. 829 - 841 (2007/10/02)
Structural modifications of an extremely potent inhibitor of dihydrofolate reductase (DHFR) activity and tumor cell growth, N-[4-[3-(2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidin-5-yl)propyl ]benzoyl]-L-glutamic acid (1), have led to the synthesis of
Cyclopentane derivatives manufacture
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, (2008/06/13)
The present invention relates to new cyclopentane derivatives having the formula STR1 and to a process for their manufacture. The compounds can be used as medicaments due to their antiprostaglandin effect.
Novel cyclopentane derivatives
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, (2008/06/13)
The present invention relates to novel not naturally occurring 10,11-dihydro-derivatives of prostaglandins of the A-series as well as a process for their preparation. The compounds of the invention have an antiprostaglandin effect and may be used as medicaments for the inhibition or suppression pharmacological properties of the prostaglandins.
