30893-58-4

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 79-11-8 chloroacetic acid 
• 3926-62-3 sodium monochloroacetic acid 
• 35285-68-8 sodium salt of ethyl-4-hydroxybenzoate 
• 29936-92-3 ethyl 4-(ethoxycarbonyl)phenoxyacetate 
• 1286895-60-0 4-(2-tert-butoxy-2-oxoethyl)benzoic acid ethyl ester 

Downstream Products

• 25389-23-5 ethyl 4-(2-hydroxyethoxy)benzoate 
• 944447-00-1 C₁₈H₂₆N₂O₆ 
• 944447-01-2 ethyl 3-{2-[(2-{[(4-carboxyphenoxy)acetyl]amino}ethyl)amino]-2-oxoethoxy}benzoate 
• 7062-75-1 2-(4-Aethoxycarbonyl-phenoxy)-peressigsaeure-tert.-butylester 
• 170799-52-7 diethyl N-<4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)ethoxy>benzoyl>-L-glutamate 
• 170799-60-7 ethyl 4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)ethoxy>benzoate 
• 149325-67-7 4-<2-(2,4-diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)ethoxy>benzoic acid 
• 170799-65-2 ethyl 4-<2-(2-cyano-3-methoxy-2-cyclopentenyl)ethoxy>benzoate 
• 1027062-64-1 4-(2-Methanesulfonyloxy-ethoxy)-benzoic acid ethyl ester 
• 41386-38-3 4-(2-Bromo-ethoxy)-benzoic acid ethyl ester 
• 56703-36-7 4-(2-Iodoethoxy)-benzoic acid ethyl ester 

Relevant academic research and scientific papers

PYRROLIDINE DERIVATIVE OR SALT THEREOF

[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).

Novel 6-5 fused ring heterocycle antifolates with potent antitumor activity: Bridge modifications and heterocyclic benzoyl isosters of 2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine antifolate

Structural modifications of an extremely potent inhibitor of dihydrofolate reductase (DHFR) activity and tumor cell growth, N-[4-[3-(2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidin-5-yl)propyl ]benzoyl]-L-glutamic acid (1), have led to the synthesis of

PEPTIDE DERIVATIVES

The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri-and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.

POLYMER SUPPORTED REAGENTS: USE OF ANION EXCHANGE RESIN IN THE SYNTHESIS OF ARYLOXY ACETIC ACIDS

Phenoxides supported on Amberlite IRA 400 on reaction with sodium salt of chloroacetic acid gave corresponding aryloxy acetic acid in high yields.Interestingly nitrophenols, 4-hydroxy coumarin and p-hydroxy ethylbenzoate gave excellent yields of the product.