56708-70-4Relevant academic research and scientific papers
Synthesis and biological screening of new cyano-substituted pyrrole fused (Iso)quinoline derivatives
Al-Matarneh, Maria Cristina,Am?randi, Roxana-Maria,Danac, Ramona,Mangalagiu, Ionel I.
, (2021/05/29)
Several new cyano-substituted derivatives with pyrrolo[1,2-a]quinoline and pyrrolo[2,1a]isoquinoline scaffolds were synthesized by the [3 + 2] cycloaddition of (iso)quinolinium ylides to fumaronitrile. The cycloimmonium ylides reacted in situ as 1,3-dipol
One-pot synthesis of pyrrolo[2,1-a]isoquinolines via tandem reactions of vinylselenonium salt, 2-bromoethanones, and isoquinoline
Li, Yunxia,Liao, Minghong,Liu, Shanshan,Mao, Deshou,Sun, Qi,Tang, E.,Zhao, Yan
, p. 1563 - 1574 (2020/01/28)
An convenient and one-pot synthesis of pyrrolo[2,1-a]isoquinolines via the tandem reaction of methyl(phenyl)vinylselenonium salt with isoquinoline and 2-bromoethanones has been developed, which features very mild conditions, available substrates, simple experimental procedures, moderate to good yields, and wide functional group tolerance.
DABCO-catalyzed multi-component domino reactions for the one-pot efficient synthesis of diverse and densely functionalized benzofurans in water
Golchin, Sajedeh,Mosslemin, Mohammad Hossein,Yazdani-Elah-Abadi, Afshin,Shams, Nasim
, p. 1735 - 1749 (2017/02/15)
An efficient, three-component strategy for the improved synthesis of a pharmaceutically interesting diverse kind of multi-functionalized benzofurans via one-pot two-step domino protocol with high diastereoselectivity in excellent yields has been established. The synthesis was achieved by reacting phenacyl bromides, N-heterocycles, aromatic aldehydes, and cyclic 1,3-dicarbonyl compounds in the presence of a catalytic amount of DABCO (1,4-diazabicyclo[2.2.2]octane) as an inexpensive, impressive, and readily available catalyst in water under reflux. In this process in total three new bonds (two C–C and one C–O) form in one pot. Short reaction time, excellent yields, no chromatographic purification, and evasion of environmentally hazardous or toxic catalysts and organic solvents in the entire reaction process may make this protocol very useful for academia and industry.
Synthesis and biological evaluation of some new indolizine derivatives as antitumoral agents
Lucescu, Liliana,B?cu, Elena,Belei, Dalila,Dubois, Jo?lle,Ghinet, Alina
, p. 479 - 488 (2016/07/19)
A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS c
Synthesis and biological evaluation of some new indolizine derivatives as antitumoral agents
Lucescu, Liliana,B?cu, Elena,Belei, Dalila,Dubois, Jo?lle,Ghinet, Alina
, p. 479 - 488 (2016/10/12)
A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS c
One-pot regio- and chemo-selective synthesis of thiaazatricyclododecane
Alizadeh, Abdolali,Bagherinejad, Akram,Bayat, Fahimeh,Zhu, Long-Guan
, p. 7070 - 7075 (2016/10/13)
A highly regio- and chemo-selective heteroannulation protocol for the synthesis of unreported polysubstituted thiaazatricyclododecanes has been developed by a sequential four-component reaction of isoquinoline, 2-bromoacetophenones, aryl isothiocyanates,
Discovery of indolizines containing triazine moiety as new leads for the development of antitumoral agents targeting mitotic events
Lucescu, Liliana,Ghinet, Alina,Belei, Dalila,Rigo, Beno?t,Dubois, Jo?lle,B?cu, Elena
supporting information, p. 3975 - 3979 (2015/08/24)
Abstract A new family of 3-aroylindolizines bearing a dimethoxytriazine unit in their position 1 was designed, synthesized and evaluated for their ability to inhibit tubulin polymerization and cellular growth in vitro. Compound 39 was the best candidate i
Pyrrolo[2,1-a]isoquinoline derivatives via 1,3-dipolar cycloaddition of isoquinolinium N-ylides (II)
Georgescu, Emilian,Dumitrescu, Denisa,Georgescu, Florentina,Draghici, Constantin,Dumitrascu, Florea
scheme or table, p. 691 - 695 (2012/04/04)
The reaction of N-isoquinolinium bromides 3 with acrylonitrile and crotononitrile as activated olefinic dipolarophiles gave in the presence of triethylamine and the oxidant tertrakis-pyridinecobalt(II) dichromate (TPCD), in DMF at 90 °C, 1-cyanopyrrolo[2,
Synthesis of benzoindolizine derivatives by reaction of trimethyl phosphite, dialkyl acetylenedicarboxylates and isoquinolinium or quinolinium bromides
Anary-Abbasinejad, Mohammad,Charkhati, Khadije,Hassanabadi, Alireza
experimental part, p. 95 - 97 (2009/11/30)
The reactive 1:1 adduct produced by the addition of trimethyl phosphite to dialkyl acetylenedicarboxylates protonated by isoquinolinium or quinolinium bromides to afford isoquinolinium or quinolinium ylides and vinyl phosphonium bromides. 1,3-Dipolar cycl
A new focused microwave approach to the synthesis of amino-substituted pyrroloisoquinolines and pyrroloquinolines via a sequential multi-component coupling process
Hopkin, Mark D.,Baxendale, Ian R.,Ley, Steven V.
, p. 1688 - 1702 (2008/12/22)
A multi-component reaction has been developed allowing direct access to pyrroloisoquinolines and pyrroloquinolines with new, electron-rich substitution patterns. The synthesised amino-substituted heterocyclic compounds and intermediates involved in their
