61001-06-7

Usage

Hazard

A reproductive hazard.

Upstream product

• 1532-84-9 isoquinolin-1-ylamine 
• 99-73-0 para-bromophenacyl bromide 
• 875289-82-0 2,4-dinitro-benzenesulfonic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester 
• 98475-05-9 α-tosyloxy-4-bromoacetophenone 
• 119-65-3 isoquinoline 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 89108-50-9 1-(1-azidovinyl)-4-bromobenzene 
• 33458-10-5 1-bromo-4-(1,2-dibromoethyl)benzene 
• 299456-72-7 1-(4-bromophenyl)ethanone O-acetyl oxime 
• 70-11-1 α-bromoacetophenone 
• 128256-28-0 C₁₄H₁₂Br₂N₂O₂S 
• 99-90-1 para-bromoacetophenone 
• 56708-70-4 1-[2-(4-bromophenyl)-2-oxoethyl]isoquinolinium bromide 

Relevant academic research and scientific papers

Three Sequential C-N Bond Formations: Tert-Butyl Nitrite as a N1 Synthon in a Three Component Reaction Leading to Imidazo[1,2-a]quinolines and Imidazo[2,1-a]isoquinolines

tert-Butyl nitrite serves the dual role of an oxidant as well as a N1 synthon in a multicomponent reaction involving quinolines, isoquinolines, and styrenes. Herein, two sp2 C-H functionalizations of styrenes and one sp2 C-H functionalization of quinolines and isoquinolines lead to the formation of fused quinolines and isoquinolines via three sequential C-N bond formations.

Copper-catalyzed c-h functionalization of pyridines and isoquinolines with vinyl azides: Synthesis of imidazo heterocycles

Copper(I) iodide-catalyzed oxidative C(sp2)-H functionalization of pyridines and isoquinolines for the synthesis of imidazo[1,2-a]pyridines and 2-phenylimidazo[2,1-a]isoquinolines with vinyl azides under mild aerobic conditions is reported. Goo

Conversion of pyridine to imidazo[1,2-a]pyridines by copper-catalyzed aerobic dehydrogenative cyclization with oxime esters

A rapid and environmentally friendly conversion of pyridine to imidazo[1,2-a]pyridines has been developed via copper-catalyzed aerobic dehydrogenative cyclization with ketone oxime esters.

Facile three-component domino reactions for the synthesis of 2-arylimidazo[1,2-a]pyridines and 2-arylimidazo[2,1-a]isoquinolines

The three-component domino reactions of pyridine/isoquinoline, phenacyl bromide, and substituted (E)-N-hydroxyarylimidoyl chloride in the presence of triethylamine afforded a series of 2-arylimidazo[1,2-a]pyridines and 2-arylimidazo[2,1-a]isoquinolines. This one pot three-component transformation presumably proceeds via ylide generation/annulation/fragmentation/dehydration domino sequence of reactions.

Synthesis of imidazo[2,1-a]isoquinolines from α-tosyloxyketones and 1-aminoisoquinoline in ionic liquid solvent

The room temperature ionic liquid n-butylpyridinium tetrafluoroborate (BPyBF4) is used as a 'green' recyclable alternative to classical molecular solvents for the cyclocondensation of α-tosyloxyketones with 1-aminoisoquinoline to prepare imidazo[2,1-a]isoquinolines in good yields.

Regioselective synthesis of 2-arylimidazo[2,1-a] isoquinolines

Substituted phenacyl bromides react with isoquinoline to form the corresponding quaternary salts which, when heated in ammonium acetate and acetic acid in the presence of Cu(II)O, undergo regioselective cyclisation to give 2-arylimidazo[2,1-a]isoquinoline

Synthesis of imidazo[1,2-a]pyridines from pyridines and p-bromophenacyl bromide O-methyloxime

p-Bromophenacyl bromide O-methyloxime reacts with pyridines in acetone to form the corresponding pyridinium salts which, when heated in methanol in the presence of Et3N, undergo cyclization followed by elimination of MeOH to give imidazo[1,2-a]pyridines.

REACTION OF α-BROMOACETOPHENONE PHENYLSULFONYLHYDRAZONES. A NEW SYNTHETIC ROUTE TO 2-ARYLIMIDAZOISOQUINOLINES AND -QUINOLINES

2-Arylimidazoisoquinolines and -quinolines were obtained in good to moderate yields by the reaction of the title hydrazones with isoquinoline and quinoline, respectively.

Synthesis and pregnancy terminating activity of 2-arylimidazo[2,1-a]isoquinolines and isoindoles

A series of 2-arylimidazo[2,1-a]isoquinolines (1-21), some 5,6-dihydro derivatives (22-28) and 2-phenyl-5H-imidazo[2,1-a]isoindole (29) were synthesized and tested for the pregnancy terminating activity in hamsters and rats. An efficient preparation of 2-