5671-99-8

Upstream product

• 13074-60-7 monoethylmaleic acid 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 15933-07-0 Ethyl 2-oxobutanoate 
• 141331-34-2 diethyl 2-ethylidenesuccinate 
• 16048-76-3 2-ethyl-3-hydroxy-succinic acid 

Downstream Products

• 636-48-6 monoethylsuccinic acid 
• 1390618-59-3 C₁₂H₁₃ClN₂O₂ 
• 1390618-60-6 C₁₁H₁₃ClN₂O 
• 1390618-58-2 C₁₂H₁₂ClNO₃ 

Relevant academic research and scientific papers

NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER

The present invention provides compounds of formula or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R1 to R4, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer.

NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER

The present invention provides HDAC inhibitors of formula (I), or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R1 to R4, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer

Preparation of (S)-2-Substituted Succinates by Stereospecific Reductions of Fumarate and Derivatives with Resting Cells of Clostridium formicoaceticum

Fumarate derivatives have been reduced to (S)-2-methylsuccinate 2a, (S)-2-ethylsuccinate 3a and (S)-2-chlorosuccinate 4a in up to 1 M concentrations with Clostridium formicoaceticum.Formate was the electron donor and viologens or anthraquinone-2,6-disulphonate acted as artificial electron mediators.Reductions with freeze-dried cells in 2H2O-buffers led to the (2R,3S)--dideuterated succinate derivatives.The productivity numbers ranged from 450 to 5000 and the enantiomeric excess of all (S)-2-substituted succinates was >/= 99percent.