56715-28-7

Usage

Uses

Used in Pharmaceutical Industry:
(R)-(-)-GLYCIDYL1-NAPHTHYLETHER is used as a key intermediate in the synthesis of Naftopidil (N213500) enantiomers for their application in the treatment of benign prostatic hyperplasia (BPH). (R)-(-)-GLYCIDYL1-NAPHTHYLETHER plays a crucial role in ensuring the correct chirality of the final product, which is essential for the drug's efficacy and safety.
Used in Chemical Synthesis:
(R)-(-)-GLYCIDYL1-NAPHTHYLETHER is also used as a versatile building block in the synthesis of various organic compounds, particularly those with chiral centers. Its unique structure allows for selective reactions and the formation of complex molecules with potential applications in different industries, such as pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 2461-42-9 3-(1-naphthyloxy)-1,2-epoxypropane 
• 62-53-3 aniline 

Downstream Products

• 525-66-6 (R)-propranolol 
• 4199-10-4 (S)-(-)-propanolol hydrochloride 
• 125474-86-4 (R)-6-[(R)-2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-heptanoic acid (4-trifluoromethyl-phenyl)-amide 
• 125452-57-5 (S)-6-[(R)-2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-heptanoic acid (4-trifluoromethyl-phenyl)-amide 
• 125452-59-7 (R)-6-[(R)-2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-heptanoic acid p-tolylamide 
• 125452-60-0 (S)-6-[(R)-2-Hydroxy-3-(naphthalen-1-yloxy)-propylamino]-heptanoic acid p-tolylamide 
• 146838-96-2 (S,S)-(-)-1-(1-Naphthyloxy)-2-hydroxy-3-N-(1-phenylethylamino)propane hydrochloride 

Relevant academic research and scientific papers

Asymmetric Hydrolytic and Aminolytic Kinetic Resolution of Racemic Epoxides using Recyclable Macrocyclic Chiral Cobalt(III) Salen Complexes

New chiral macrocyclic cobalt(III) salen complexes were synthesized and used as catalyst for the asymmetric kinetic resolution (AKR) of terminal epoxides and glycidyl ethers with aromatic/aliphatic amines and water as nucleophiles. This is the first occasion where a Co(III) salen complex demonstrated its ability to catalyze AKR as well as hydrolytic kinetic resolution (HKR) reactions. Excellent enantiomeric excesses of the epoxides, the corresponding amino alcohols and diols (upto 99%) with quantitative yields were achieved by using the chiral Co(III) salen complexes in dichloromethane at room temperature. This protocol was further extended for the synthesis of two important drug molecules, i.e., (S)-propranolol and (R)-naftopidil. The catalytic system was also explored for the synthesis of chirally pure diols and chiral cyclic carbonates using carbon dioxide as a greener renewable C1 source. The catalyst was recycled for upto 5 catalytic cycles with retention of enantioselectivity. (Figure presented.).