56717-04-5

Upstream product

• 14807-16-0 9-Anilino-1,2,3,4-tetrahydroacridine 
• 38778-79-9 ethyl 2-(N-phenylamino)-1-cyclohexene-1-carboxylate 
• 108-94-1 cyclohexanone 
• 118-92-3 anthranilic acid 
• 13161-85-8 1,2,3,4,9,10-hexahydroacridin-9-one 
• 3898-08-6 1,1-diphenylthiourea 
• 6833-04-1 N,N'-Diphenylpimelamide 

Downstream Products

• 5396-30-5 9-chloro-1,2,3,4-tetrahydroacridine 
• 443662-39-3 7-bromo-1,2,3,4-tetrahydro-acridin-9-ol 
• 578-95-0 10H-acridin-9-one 
• 260-94-6 acridine 
• 7032-37-3 4-Morpholino-2,3-tetramethylenequinoline 
• 53618-67-0 6-Brom-4-chlor-2,3-tetramethylenchinolin 
• 321-64-2 tacrin 

Relevant academic research and scientific papers

Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity

A series of tacrine-ebselen hybrids were synthesised and evaluated as possible multifunctional anti-Alzheimer's disease (AD) agents. Compound 6i, which is tacrine linked with 5,6-dimethoxybenzo[d][1,2]selenazol-3(2H)-one by a six-carbon spacer, was the most potent acetylcholinesterase (AChE) and butylcholinesterase (BuChE) inhibitor, with IC50 values of 2.55 and 2.80 nM, respectively. Furthermore, this compound demonstrated similar hydrogen peroxide and peroxynitrite scavenging activity as ebselen by horseradish peroxidase assay and peroxynitrite scavenging activity assay, indicating that this hybrid is a good multifunctional drug candidate for the treatment of AD.

Synthesis and antitumor activity of fused tetracyclic quinoline derivatives

Several fused tri- and tetracyclic quinolines (I and II) with [2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino or [3-(N,N-dimethylamino)propyl]amino side chains were prepared, and their DNA intercalative properties, KB cytotoxicity, antitumor activity (P388 leukemia), and ability to induce topoisomerase II dependent DNA cleavage were investigated. Some compounds having both intercalative ability and KB cytotoxicity were found to be inactive in vivo. However, a positive correlation was seen between the ability to induce topoisomerase II dependent DNA cleavage and antitumor activity in vivo. The indeno- (13a), benzofuro- (21a), and benzothieno- (22a) quinoline derivatives exhibited potent antitumor activities in vitro and in vivo, comparable to those of m-AMSA. They also intercalate DNA and induce topoisomerase II dependent DNA cleavage. Extended screening of 13a showed it to be active against solid tumors such as M5076 sarcoma, B16 melanoma, and colon 38 carcinoma.