56741-26-5

Basic information

• Product Name: Benzene, 1,4-dimethoxy-2,5-dinitro-
• CAS NO: 56741-26-5
• Molecular Formula: C8H8N2O6
• Molecular Weight: 228.161
• Mol File: 56741-26-5.mol

Chemical Properties

• CAS DataBase Reference: Benzene, 1,4-dimethoxy-2,5-dinitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,4-dimethoxy-2,5-dinitro-(56741-26-5)
• EPA Substance Registry System: Benzene, 1,4-dimethoxy-2,5-dinitro-(56741-26-5)

Safety Data

• Hazardous Substances Data: 56741-26-5(Hazardous Substances Data)

Upstream product

• 93-02-7 2,5-dimethoxybenzaldehyde 
• 150-78-7 1,4-dimethoxybezene 
• 51560-21-5 1,4-diiodo-2,5-dimethoxybenzene 
• 6301-35-5 1-iodo-2,5-dimethoxy-4-nitro-benzene 

Downstream Products

• 17626-02-7 2,5-dimethoxy-p-phenylenediamine 

Relevant articles and documents

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A molecular turnstile T1 based on a luminescent pyridyl-benzimidazole stator and a rotor containing a pyridyl coordinating site is designed and its multi-step synthesis is described. The turnstile T1 undergoes free rotation of the rotor around the stator.

Method for nitrating aromatic compound by using nitrate under the action of auxiliary agent

The invention discloses a method for nitrating an aromatic compound by using a nitrate under the action of an auxiliary agent, and provides an aromatic nitro compound preparation method, which comprises: in the presence of an external action and an auxiliary agent, carrying out a nitrating reaction on an aromatic compound and a metal nitrate or a hydrate thereof to obtain the aromatic nitro compound, wherein the external action can cause the physical and/or chemical property change of a substance, the auxiliary agent is a substance having water absorbing ability, the external action can be mechanical force or heating, and the mechanical force can be any one selected from compression, shearing, impacting, friction, stretching, bending and vibration. According to the present invention, the method does not require any solvents so as to avoid the generation of the waste liquid; the acidic substance is not used, such that the treatment is simple after the reaction is completed, and the equipment is not damaged; the added auxiliary agent can be theoretically recycled; and the method has extremely high conversion rate and extremely high selectivity, and can be used for the nitration of conventional aromatic compounds.

Exploration of the Photodegradation of Naphtho[2,3-g] quinoxalines and Pyrazino[2,3-b]phenazines

Nitrogen-containing polycyclic aromatic hydrocarbons are very attractive compounds for organic electronics applications. Their low-lying LUMO energies points towards a potential use as n-type semiconductors. Furthermore, they are expected to be more stable under ambient conditions, which is very important for the formation of semiconducting films, where materials with high purity are needed. In this study, the syntheses of naphtho[2,3-g]quinoxalines and pyrazino[2,3-b]phenazines is presented by using reaction conditions, that provide the desired products in high yields, high purity and without time-consuming purification steps. The HOMO and LUMO energies of the compounds are investigated by cyclic voltammetry and UV/Vis spectroscopy and their dependency on the nitrogen content and the terminal substituents are examined. The photostability and the degradation pathways of the naphtho[2,3-g]quinoxalines and pyrazino[2,3-b]phenazines are explored by NMR spectroscopy of irradiated samples affirming the large influence of the nitrogen atoms in the acene core on the degradation process during the irradiation. Finally, by identifying the degradations products of 2,3-dimethylnaphtho[2,3-g]quinoxaline it is possible to track down the most reactive position in the compound and, by blocking this position with nitrogen, to strongly increase the photostability.

Diastereospecific enolate addition and atom-efficient benzimidazole synthesis for the production of l/t calcium channel blocker act-280778

A scalable access to 1 (ACT-280778), a potent L/T calcium channel blocker, has been developed. The synthesis, amenable to kilogram manufacturing, comprises 10 chemical steps from enantiomerically pure 5-phenylbicyclo[2.2.2]oct-5-en-2-one (3) and 1,4-dimethoxybenzene with a longest linear sequence of 7 steps. Key to the success of this fit-for-purpose approach are a robust and atom-efficient access to benzimidazole 4, the substrate-controlled diastereoselective enolate addition toward carboxylic acid 2 that was isolated by simple crystallization with high dr (>99:1), the convenient selective N-deacylation of intermediate 10, and the identification of a suitable solid form of 1 as the bis-maleate salt (1·2 C4H4O4). As an illustration of the robustness of this process, 14 kg of drug substance, suitable for human use, was produced with an overall yield of 38% over the longest linear sequence (7 steps).

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Dynamic [2]catenanes based on a hydrogen bonding-mediated bis-zinc porphyrin foldamer tweezer: A case study

(Chemical Equation Presented) This paper describes the self-assembly of a new class of three-component dynamic [2]catenanes, which are driven or stabilized by intramolecular hydrogen bonding, coordination, and electrostatic interaction. One of the component molecules 2, consisting of an aromatic oligoamide spacer and two peripheral zinc porphyrin units, was designed to adopt a folded preorganized conformation, which is stabilized by consecutive intramolecular three-centered hydrogen bonds. Component molecule 3 is a linear secondary ammonium bearing two peripheral pyridine units, which was designed to form a 1:1 complex with 24-crown-8 (5). The 1H NMR and UV-vis experiments in CDCl3-CD3CN (4:1 v/v) revealed that, due to the preorganized U-shaped feature, 2 could efficiently bind 3 through the cooperative zinc-pyridine coordination to generate highly stable 1:1 complex 2·3. Adding 5 to the 1:1 solution of 2 and 3 led to the formation of dynamic three-component [2]catenane 2·3·5 as a result of the threading of 3 through 5. 1H NMR studies indicated that in the 1:1:1 solution (3 mM) [2]catenane 2·3·5 was generated in 55% yield at 25°C. The yield was increased with the reduction of the temperature and [2]catenane could be produced quantitatively in a 1:1:2 solution ([2] = 3 mM) at -13°C. Replacing 3 with 1,2-bis(4,4′-bipyridinium)ethane (4) in the three-component solution could also give rise to similar dynamic [2]-catenane 2·4·5 albeit in slightly lower yield.