56751-27-0Relevant academic research and scientific papers
Palladium-catalyzed, chelation-assisted stereo- and regioselective synthesis of tetrasubstituted olefins by oxidative heck arylation
Lee, Hyun Seung,Kim, Ko Hoon,Kim, Sung Hwan,Kim, Jae Nyoung
supporting information, p. 2419 - 2426 (2012/11/07)
An efficient synthesis of tetrasubstituted olefins was achieved via a palladium-catalyzed, chelation-assisted oxidative Heck arylation protocol from trisubstituted olefins bearing a tether with a directing group in a completely stereo- and regioselective manner. The stereo- and regioselectivity as well as excellent yields of tetrasubstituted olefins originated from the stabilization of a palladium intermediate by chelation between the palladium center and a directing group. Copyright
