5677-84-9

Upstream product

• 7713-77-1 4,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 50-00-0 formaldehyd 
• 60-80-0 antipyrine 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 622-36-6 1-methyl-2-phenylhydrazine 
• 100-63-0 phenylhydrazine 

Downstream Products

• 98395-59-6 1-Methoxymethyl-4,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 60473-57-6 3-Bromomethyl-2,4-dimethyl-1-phenyl-3-pyrazolin-5-on 
• 125689-41-0 4,5-bis-diethylaminomethyl-1-methyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 110249-92-8 1-methyl-2,5-diphenyl-1,4,5,6-tetrahydro-2H-pyrrolo[3,4-c]pyrazol-3-one 

Relevant academic research and scientific papers

PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS

Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, X, and n are as defined for Formula (I) in the description, processes for the preparation of the compounds and new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and the use of the compounds in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction.

Mechanisms of Heterocycle Ring Formation. Part 5. A Carbon-13 Nuclear Magnetic Resonance Study of Pyrazolinone Synthesis by the Reaction of β-Ketoesters with Substituted Hydrazines

The 16 reactions between each of four hydrazines and four β-ketoesters have been followed by 13C n.m.r. spectroscopy.Peaks were assigned to starting materials, intermediates, and products, and reaction mechanisms determined and rationalized.Most rections proceed by attack of the least hindered hydrazine nitrogen atom on the keto carbon group of the ketoester.Relative rates of nucleophilic attack determine the build-up of intermediate and in some cases the nature of the products formed.